Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte chemie international edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

C Li, Y Pang, Y Xu, M Lu, L Tu, Q Li… - Chemical Society …, 2023 - pubs.rsc.org
Metal agents have made incredible strides in preclinical research and clinical applications in
recent years, but their short emission/absorption wavelengths continue to be a barrier to …

Latest developments in metal complexes as anticancer agents

R Paprocka, M Wiese-Szadkowska… - Coordination Chemistry …, 2022 - Elsevier
Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018 …

Ferroptosis photoinduced by new cyclometalated iridium (III) complexes and its synergism with apoptosis in tumor cell inhibition

H Yuan, Z Han, Y Chen, F Qi, H Fang, Z Guo… - Angewandte …, 2021 - Wiley Online Library
Limited therapeutic efficacy to hypoxic and refractory solid tumors has hindered the practical
application of photodynamic therapy (PDT). Two new benzothiophenylisoquinoline (btiq) …

A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor

B Tian, S Liu, C Yu, S Liu, S Dong… - Advanced Functional …, 2023 - Wiley Online Library
As a less O2‐dependent photodynamic therapy (PDT), type I PDT is an effective approach to
overcome the hypoxia‐induced low efficiency against solid tumors. However, the commonly …

Highly Efficient Far‐Red/NIR‐Absorbing Neutral Ir (III) Complex Micelles for Potent Photodynamic/Photothermal Therapy

B Liu, J Jiao, W Xu, M Zhang, P Cui, Z Guo… - Advanced …, 2021 - Wiley Online Library
A critical issue in photodynamic therapy (PDT) is inadequate reactive oxygen species (ROS)
generation in tumors, causing inevitable survival of tumor cells that usually results in tumor …

Intraligand excited states turn a ruthenium oligothiophene complex into a light-triggered Ubertoxin with anticancer effects in extreme hypoxia

JA Roque III, HD Cole, PC Barrett… - Journal of the …, 2022 - ACS Publications
Ru (II) complexes that undergo photosubstitution reactions from triplet metal-centered (3MC)
excited states are of interest in photochemotherapy (PCT) due to their potential to produce …

A near-infrared light-activatable Ru (ii)-coumarin photosensitizer active under hypoxic conditions

E Ortega-Forte, A Rovira, M López-Corrales… - Chemical …, 2023 - pubs.rsc.org
Photodynamic therapy (PDT) represents a promising approach for cancer treatment.
However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) …