Klinische Entwicklung von Metallkomplexen als Photosensibilisatoren für die photodynamische Therapie von Krebs

J Karges - Angewandte Chemie, 2022 - Wiley Online Library
Krebs hat sich in den letzten Jahrzehnten zu einer der häufigsten krankheitsbedingten
Todesursachen der Welt entwickelt. Neben den am häufigsten angewendeten Techniken …

Heavy atom effect through chalcogen substitution in Red Nile dye: a theoretical investigation

ME Alberto, M Prejanò, T Marino… - Theoretical Chemistry …, 2023 - Springer
Abstract A DFT and TDDFT study has been carried out on Red Nile dye (RN) and on two
chalcogens-derivatives in which the carbonyl-oxygen was replaced by Sulfur-(SNR) and …

[HTML][HTML] Nanomolar concentrations of the photodynamic compound TLD-1433 effectively inactivate numerous human pathogenic viruses

KM Coombs, KKM Glover, R Russell, P Kaspler… - Heliyon, 2024 - cell.com
The anti-viral properties of a small (≈ 1 kDa), novel Ru (II) photo dynamic compound (PDC),
referred to as TLD-1433 (Ruvidar™), are presented. TLD-1433 had previously been …

[HTML][HTML] Synthesis, Characterization, Thermal Analysis, DFT, and Cytotoxicity of Palladium Complexes with Nitrogen-Donor Ligands

SR Majeed, MA Amin, FA Attaby, ME Alberto… - Molecules, 2022 - mdpi.com
Three new palladium complexes ([Pd (DABA) Cl2],[Pd (CPDA) Cl2], and [Pd (HZPY) Cl2])
bearing dinitrogen ligands (DABA: 3, 4-diaminobenzoic acid; CPDA: 4-chloro–o …

[HTML][HTML] Rational design by DFT calculations of new metal complexes for photodynamic therapy based on an H2O2-Responsive Ir (III) photosensitizer activatable in …

P Barretta, F Ponte, G Mazzone - Journal of Molecular Liquids, 2024 - Elsevier
A series of complexes based on the structure of an H 2 O 2-responsive Ir (III) phenylpyridine
(ppy)-containing complex were designed. The effect of changing the conjugation in the ppy …

[HTML][HTML] Stacking effects on Anthraquinone/DNA charge-transfer electronically excited states

G Cárdenas, JJ Nogueira - Molecules, 2020 - mdpi.com
The design of more efficient photosensitizers is a matter of great importance in the field of
cancer treatment by means of photodynamic therapy. One of the main processes involved in …

Advances in Metal-Based Compounds as Emerging Therapeutics for Cancer Treatment

ML Low, CW Mai, SP Yeap, YY Then, MS Rajagopal… - 2024 - Springer
This chapter explores the transformative role of metal-based compounds in diverse cancer
treatment strategies. Metal complexes enhance immunotherapy by modulating immune …

Configurable automated well plate illuminator for in vitro research in drug discovery and optogenetics

E Kokko, R Perttilä, L Orsila, Z Ylöniemi… - … , and Analysis of …, 2021 - spiedigitallibrary.org
There is a demand for a robust and flexible illumination and screening instrument for
preclinical light-sensitive drug development and optogenetic research. While there is a great …

[引用][C] Red-Shifting Blue Light Photoredox Catalysis for Organic Synthesis: A Graphical Review

KA Xiea, SL Goldschmida, TC Sherwoodc… - 2023

Towards high-throughput light-activated drug discovery using automated plate illuminator

R Perttilä, J Roque III, L Orsila… - … and Techniques in …, 2021 - spiedigitallibrary.org
There is an ongoing need in photodynamic therapy (PDT) research to develop highly active
photosensitizers (PSs) with improved characteristics combined with optimized treatment …