The active compound in herbal cannabis, Δ9‐tetrahydrocannabinol, exerts all of its known
central effects through the CB1 cannabinoid receptor. Research on cannabinoid …

Cannabinoids have a long history of consumption for recreational and medical reasons. The
primary active constituent of the hemp plant Cannabis sativa is Δ9-tetrahydrocannabinol (Δ9 …

Behavioural and pharmacological effects of Δ9‐tetrahydrocannabinol (THC) and nicotine
are well known. However, the possible interactions between these two drugs of abuse …

To date, N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol are the
best studied endocannabinoids and are thought to act as retrograde messengers in the …

Two are the issues on cannabis addiction that provoke more controversy from a research
perspective. The first one is related to the development of tolerance phenomena and, in …

Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

The goal of the present study was to elucidate the relationship between cannabinoid and
opioid systems in drug dependence. The CB1cannabinoid receptor antagonist SR 141716A …

Tolerance and dependence induced by chronic Δ‐9‐tetrahydrocannabinol (THC)
administration were investigated in mice. The effects on body weight, analgesia and …

The use of marijuana for recreational and medicinal purposes has resulted in a large
prevalence of chronic marijuana users. Consequences of chronic cannabinoid …

There is substantial clinical evidence that Δ9-tetrahydrocannabinol (Δ9-THC) and its
synthetic analogs (nabilone and levonantradol) can prevent emesis in cancer patients …