Antibiotics have made it possible to treat bacterial infections such as meningitis and
bacteraemia that, prior to their introduction, were untreatable and consequently fatal …

Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

This chapter analyzes the epidemiology of Carbapenem-Resistant Enterobacteriaceae
(CRE) as well as current and future treatment options against the increasingly resistant …

The increasing prevalence of antibiotic resistance is a threat to human health, particularly
within vulnerable populations in the hospital and acute care settings. This leads to …

Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing
serious nosocomial infections, which is considered as the most threatening Gram-negative …

Abstract Multidrug-resistant (MDR) Gram-negative bacteria (GNB) pose a critical threat to
global healthcare, worsening outcomes and increasing mortality among infected patients …

Multidrug resistance (MDR) represents a serious global threat due to the rapid global spread
and limited antimicrobial options for treatment of difficult-to-treat (DTR) infections sustained …

A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix
produced by themselves. Many types of microorganisms that are found on living hosts or in …