Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …

Abstract Purpose of Review Recent treatment advances in both acute myeloid leukemia and
acute lymphoblastic leukemia have drastically improved outcomes for these diseases, but …

The present review aimed to establish an understanding of the pathophysiology of
leptomeningeal disease as it relates to late-stage development among different cancer …

Chimeric antigen receptor (CAR) T-cell systemic immunotherapy has revolutionized how
clinicians treat several refractory and relapsed hematologic malignancies. Due to its peculiar …

The role of the vascular microenvironment is increasingly studied in acute myeloid
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …

Background and objective Central nervous system (CNS) infiltration commonly occurs in
children with acute lymphoblastic leukemia (ALL). Nevertheless, CNS infiltration is rarely …

Acute myeloid leukemia (AML) comprises a heterogeneous group of aggressive blood
malignancies that arise from clonal expansion of malignant hematopoietic precursor cells in …

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a hematological malignancy
characterized by recurrent skin nodules, an aggressive clinical course with rapid …

Acute lymphocytic leukemia (ALL) is the most frequent form of all childhood leukemias,
mostly affecting children between 2 and 4 years old. Oral symptoms, such as mouth ulcers …

Objective: To investigate the cytotoxic effect of polysaccharides derived from Ganoderma
lucidum on T lymphocyte leukemia cells. Methods: Water-soluble polysaccharides were …