Nociception and pain is a large field of both neuroscience and medical research. Over time,
various tests and models were developed in rodents to provide tools for fundamental and …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Objective: Although postoperative cognitive dysfunction (POCD) often complicates recovery
from major surgery, the pathogenic mechanisms remain unknown. We explored whether …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain, including neuropathic pain. While this comorbidity is clinically …

BACKGROUND: Chronic pain is clinically associated with the development of affective
disorders. However, studies in animal models of neuropathic pain are contradictory and the …

Pain and depression are two highly prevalent and deleterious disorders with significant
socioeconomic impact to society. Clinical observations have long recognized the co …

In human conditions, chronic pain is associated with widespread anatomical changes in the
brain. Nevertheless, little is known about the time course of these changes or the …

Fear extinction is a form of new learning that results in the inhibition of conditioned fear. Trait
deficits in fear extinction are a risk factor for anxiety disorders. There are few examples of …

Despite the impact of chronic pain on the quality of life in patients, including changes to
affective state and daily life activities, rodent preclinical models rarely address this aspect of …