Alzheimer's disease: experimental models and reality

E Drummond, T Wisniewski - Acta neuropathologica, 2017 - Springer
Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

[HTML][HTML] Alzheimer's disease, oligomers, and inflammation

G Forloni, C Balducci - Journal of Alzheimer's Disease, 2018 - content.iospress.com
The production of soluble amyloid-β oligomers (AβOs) and the activation of inflammation are
two important early steps in the pathogenesis of Alzheimer's disease (AD). The central role …

[HTML][HTML] Infectious origin of Alzheimer's disease: Amyloid beta as a component of brain antimicrobial immunity

I Vojtechova, T Machacek, Z Kristofikova… - PLoS …, 2022 - journals.plos.org
The amyloid cascade hypothesis, focusing on pathological proteins aggregation, has so far
failed to uncover the root cause of Alzheimer's disease (AD), or to provide an effective …

[HTML][HTML] Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: at a glance

MM Rhaman, MR Islam, S Akash, M Mim… - Frontiers in Cell and …, 2022 - frontiersin.org
In recent decades, research scientists, molecular biologists, and pharmacologists have
placed a strong emphasis on cutting-edge nanostructured materials technologies to …

[HTML][HTML] APOE-amyloid interaction: Therapeutic targets

T Wisniewski, E Drummond - Neurobiology of disease, 2020 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that is growing in
prevalence globally. It is the only major cause of death without any effective …

[HTML][HTML] Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease

SO Rahman, BP Panda, S Parvez, M Kaundal… - Biomedicine & …, 2019 - Elsevier
With the constant failure of the clinical trials continuous exploration of a therapeutic target
against Alzheimer's disease (AD) is the utmost need. Numerous studies have supported the …

Advance of sporadic Alzheimer's disease animal models

L Zhang, C Chen, MSH Mak, J Lu, Z Wu… - Medicinal research …, 2020 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disease. In the past decades, numbers of promising drug candidates …

Prevalence of obesity in India and its neurological implications: a multifactor analysis of a nationwide cross-sectional study

M Venkatrao, R Nagarathna… - Annals of …, 2020 - journals.sagepub.com
Background: India is undergoing a rapid epidemiological transition, from underweight to
overweight/obese population. Obesity is a major risk factor in type 2 diabetes and …

[HTML][HTML] Diagnostic accuracy of blood-based biomarker panels: a systematic review

A Hardy-Sosa, K León-Arcia… - Frontiers in aging …, 2022 - frontiersin.org
Background Because of high prevalence of Alzheimer's disease (AD) in low-and middle-
income countries (LMICs), there is an urgent need for inexpensive and minimally invasive …

[HTML][HTML] Navigating the chemical space of multitarget-directed ligands: from hybrids to fragments in Alzheimer's disease

F Prati, A Cavalli, ML Bolognesi - Molecules, 2016 - mdpi.com
Multitarget drug discovery is one of the hottest topics and most active fields in the search for
new molecules against Alzheimer's disease (AD). Over the last 20 years, many promising …