T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
CA Klebanoff, SS Chandran, BM Baker… - Nature Reviews Drug …, 2023 - nature.com
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
Chimeric antigen receptor T cell persistence and memory cell formation
AD McLellan… - Immunology and cell …, 2019 - Wiley Online Library
It is now becoming clear that less differentiated naive and memory T cells are superior to
effector T cells in the transfer of immunity for adoptive cell therapy. This review will outline …
effector T cells in the transfer of immunity for adoptive cell therapy. This review will outline …
T cells specific for α-myosin drive immunotherapy-related myocarditis
ML Axelrod, WC Meijers, EM Screever, J Qin… - Nature, 2022 - nature.com
Immune-related adverse events, particularly severe toxicities such as myocarditis, are major
challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy. The …
challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy. The …
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA
Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes
derived from recurrently mutated driver genes. Here we describe a high-throughput platform …
derived from recurrently mutated driver genes. Here we describe a high-throughput platform …
Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells
Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited
functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) …
functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) …
A human CD137× PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
C Geuijen, P Tacken, LC Wang, R Klooster… - Nature …, 2021 - nature.com
Immune checkpoint inhibitors demonstrate clinical activity in many tumor types, however,
only a fraction of patients benefit. Combining CD137 agonists with these inhibitors increases …
only a fraction of patients benefit. Combining CD137 agonists with these inhibitors increases …
Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
CM Laumont, T Daouda, JP Laverdure… - Nature …, 2016 - nature.com
In view of recent reports documenting pervasive translation outside of canonical protein-
coding sequences, we wished to determine the proportion of major histocompatibility …
coding sequences, we wished to determine the proportion of major histocompatibility …
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
The biological determinants of sensitivity and resistance to immune checkpoint blockers are
not completely understood. To elucidate the role of intratumoral T-cells and their association …
not completely understood. To elucidate the role of intratumoral T-cells and their association …
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
G Ehx, JD Larouche, C Durette, JP Laverdure… - Immunity, 2021 - cell.com
Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly
because of the lack of actionable immune targets. Using an original proteogenomic …
because of the lack of actionable immune targets. Using an original proteogenomic …
Targeting LAG-3 and PD-1 to enhance T cell activation by antigen-presenting cells
FS Lichtenegger, M Rothe, FM Schnorfeil… - Frontiers in …, 2018 - frontiersin.org
Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell
responses directed against tumor-associated antigens, resulting in significantly prolonged …
responses directed against tumor-associated antigens, resulting in significantly prolonged …