A potential link between inflammation and cancer has been suspected for over a century, but
the exact molecular mechanisms connecting the two remained nebulous. We proposed that …

Lysosomal-mediated degradation of intracellular lipids, proteins and organelles, known as
autophagy, represents a inducible adaptive response to lung injury resulting from exposure …

It is intriguing that some pan-caspase inhibitors such as zVAD-fmk (zVAD) are capable of
inducing necrotic cell death in a selected group of cells. As earlier reports from our …

To the Editor—The recent breakthroughs in the development of optical nanoscopy have
provided unprecedented views of the inner workings of cells. Stimulated emission depletion …

The progression of neurodegenerative disorders is mainly characterized by immense
neuron loss and death of glial cells. The mechanisms which are active and regulate …

Many of the cellular responses that occur in activated platelets resemble events that take
place following activation of cell-death pathways in nucleated cells. We tested the …

Minocycline has beneficial effects in early brain injury (EBI) following subarachnoid
hemorrhage (SAH); however, the molecular mechanisms underlying these effects have not …

Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune
responses. Recently, we found that Mtb uses the protein CpnT to kill human macrophages …

Over the past decade there has been considerable progress in elucidating the signaling
pathways involved in cardioprotection. Considerable recent data suggest that many of these …

Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe, debilitating
condition affecting patients with cancer and patients with osteoporosis who have been …