Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Non-alcoholic fatty liver disease (NAFLD), as one of the main causes of chronic liver disease
worldwide, encompasses a spectrum of liver conditions that are not caused by other …

Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease caused by
deficient activity of acid sphingomyelinase (ASM) enzyme, leading to the accumulation of …

Background Icariin (ICA), an active ingredient extracted from Epimedium species, has
shown promising results in the treatment of Alzheimer's disease (AD), although its potential …

Aims Sphingomyelin is an abundant component of the presynaptic membrane and an
organizer of lipid rafts. In several pathological conditions, sphingomyelin is hydrolyzed due …

The mariculture environment is a sink of microplastics (MPs) due to its enclosed nature and
mass use of plastics. Nanoplastics (NPs) are MPs with a diameter< 1 μm that have a more …

Neurotransmitter release from sympathetic terminals is a key avenue for heart regulation.
Herein, presynaptic exocytotic activity was monitored in mice atrial tissue using a false …

Glioblastoma (GBL) is the most common (60–70% of primary brain tumours) and the most
malignant of the glial tumours. Although current therapies remain palliative, they have been …

Purinergic signalling is a receptor-mediated process characterized by the binding of
extracellular nucleotides and nucleosides to purinergic receptors, which results in the …

Amyotrophic Lateral Sclerosis (ALS), Spinal Bulbar Muscular Atrophy (SBMA), and Spinal
Muscular Atrophy (SMA) are motor neuron diseases (MNDs) characterised by progressive …