Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases

Z Szekanecz, IB McInnes, G Schett… - Nature Reviews …, 2021 - nature.com
Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications

BR England, GM Thiele, DR Anderson, TR Mikuls - Bmj, 2018 - bmj.com
Rheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity
and mortality from cardiovascular disease. Mechanisms linking rheumatoid arthritis and …

Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - Signal transduction and …, 2023 - nature.com
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Extracellular matrix dynamics in vascular remodeling

Z Ma, C Mao, Y Jia, Y Fu… - American Journal of …, 2020 - journals.physiology.org
Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …

Extra-articular rheumatoid arthritis

E Marcucci, E Bartoloni, A Alunno, MC Leone, G Cafaro… - 2018 - reumatismo.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly affects the joints,
though a consistent proportion of patients may also display extra articular manifestations …

The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases

CJ Carter, J France, SJ Crean… - Frontiers in aging …, 2017 - frontiersin.org
Periodontal disease is of established etiology in which polymicrobial synergistic ecology has
become dysbiotic under the influence of Porphyromonas gingivalis. Following breakdown of …

Oxidative stress-mediated alterations in histone post-translational modifications

JL García-Giménez, C Garcés, C Romá-Mateo… - Free Radical Biology …, 2021 - Elsevier
Epigenetic regulation of gene expression provides a finely tuned response capacity for cells
when undergoing environmental changes. However, in the context of human physiology or …

Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer's disease

I Olsen, SK Singhrao, J Potempa - Journal of oral microbiology, 2018 - Taylor & Francis
ABSTRACT Periodontitis, rheumatoid arthritis (RA), atherosclerosis (AS), and Alzheimer's
disease (AD) are examples of complex human diseases with chronic inflammatory …

Innate and adaptive immunity in cardiovascular calcification

LSA Passos, A Lupieri, D Becker-Greene, E Aikawa - Atherosclerosis, 2020 - Elsevier
Despite the focus placed on cardiovascular research, the prevalence of vascular and
valvular calcification is increasing and remains a leading contributor of cardiovascular …

Atherosclerosis in rheumatoid arthritis: promoters and opponents

F Carbone, A Bonaventura, L Liberale… - Clinical reviews in …, 2020 - Springer
Substantial epidemiological data identified cardiovascular (CV) diseases as a main cause of
mortality in patients with rheumatoid arthritis (RA). In light of this, RA patients may benefit …