Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

Diabetic retinopathy continues to be the leading cause of legal blindness among working-
age individuals. The earliest histological features of diabetic retinopathy include neuroretinal …

Easy observation of the fundus oculi makes retinopathy the most frequently reported chronic
complication of diabetes and, consequently, the one we know best in terms of epidemiology …

Diabetic neuropathy is the most common peripheral neuropathy in western countries.
Although every effort has been made to clarify the pathogenic mechanism of diabetic …

OBJECTIVE—To test the hypothesis that a reduction of somatostatin (SST) in the retina
exists in patients without clinically detectable diabetic retinopathy and that it is associated …

Diabetic retinopathy (DR) is the most severe of several ocular complications of diabetes. The
earliest clinical signs of DR are microaneurysms and haemorrhages. Later signs include …

Homeostatic mechanisms normally maintain the plasma glucose concentration within
narrow limits despite major fluctuations in supply and demand. There is increasing evidence …

The development of diabetic nephropathy in patients with Type I (insulin-dependent) and
Type II (non-insulin-dependent) diabetes mellitus is still a huge clinical problem associated …

Aims/hypothesis The association of insulin detemir with non-esterified fatty acid binding sites
on albumin may limit its transfer from the circulation into the extravascular extracellular …