Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment

Y Li, Y Zhou, W Zhong, X Zhu, Y Chen… - Annals of …, 2023 - Wiley Online Library
Objective Choroid plexus (CP) is a key regulator in cerebrospinal fluid production, but its
contribution to glymphatic clearance function and association with white matter …

Gray matter reserve determines glymphatic system function in young‐onset Alzheimer's disease: evidenced by DTI‐ALPS and compared with age‐matched controls

HI Chang, CW Huang, SW Hsu… - Psychiatry and …, 2023 - Wiley Online Library
Background The diffusion tensor imaging analysis along the perivascular space (ALPS)‐
index can be used to model the glymphatic system in vivo. Aim This study explores putative …

Association of cognition and brain reserve in aging and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS)

WC Hsiao, HI Chang, SW Hsu, CC Lee, SH Huang… - Neuroscience, 2023 - Elsevier
The glymphatic system is a fluid-clearance pathway that clears cerebral waste products, and
its dysfunction has been associated with protein aggregation diseases such as Alzheimer's …

Noninvasive magnetic resonance imaging measures of glymphatic system activity

K Kamagata, Y Saito, C Andica… - Journal of Magnetic …, 2024 - Wiley Online Library
The comprehension of the glymphatic system, a postulated mechanism responsible for the
removal of interstitial solutes within the central nervous system (CNS), has witnessed …

Diffusion-weighted image analysis along the perivascular space (DWI–ALPS) for evaluating interstitial fluid status: age dependence in normal subjects

T Taoka, R Ito, R Nakamichi, T Nakane, M Sakai… - Japanese Journal of …, 2022 - Springer
Purpose The purpose of this study was to evaluate the interstitial fluid status in a wide range
of age groups using diffusion-weighted image analysis along the perivascular space (DWI …

Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS)

Y Saito, Y Hayakawa, K Kamagata, J Kikuta… - Japanese Journal of …, 2023 - Springer
Purpose This study aimed to evaluate the relationship between sleep quality as assessed
using the Pittsburgh Sleep Quality Index (PSQI) and the index of diffusivity along the …

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Y Qin, X Li, Y Qiao, H Zou, Y Qian, X Li, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Purpose Brain glymphatic dysfunction is involved in the pathologic process of acute
ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in …

Interstitial fluidopathy of the central nervous system: an umbrella term for disorders with impaired neurofluid dynamics

T Taoka, R Ito, R Nakamichi, T Nakane… - … Resonance in Medical …, 2024 - jstage.jst.go.jp
Interest in interstitial fluid dynamics has increased since the proposal of the glymphatic
system hypothesis. Abnormal dynamics of the interstitial fluid have been pointed out to be an …

Vascular risk factors and astrocytic marker for the glymphatic system activity

YC Wei, CCH Hsu, WY Huang, C Lin, CK Chen… - La radiologia …, 2023 - Springer
Objectives Glymphatic system maintains brain fluid circulation via active transportation of
astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along …

Glymphatic dysfunction mediates the influence of white matter hyperintensities on episodic memory in cerebral small vessel disease

Z Ke, Y Mo, J Li, D Yang, L Huang, Z Yang, R Qin… - Brain Sciences, 2022 - mdpi.com
Glymphatic dysfunction has been linked to cognitive decline in several neurodegenerative
diseases. In cerebral small vessel disease (CSVD), the mechanism of white matter …