Diffusion-weighted imaging reveals impaired glymphatic clearance in idiopathic intracranial hypertension

D Schartz, A Finkelstein, N Hoang… - American Journal …, 2024 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The pathophysiology underlying idiopathic intracranial
hypertension (IIH) remains incompletely understood. While one theory postulates impaired …

[HTML][HTML] Assessment of factors influencing glymphatic activity and implications for clinical medicine

A Gędek, D Koziorowski, S Szlufik - Frontiers in Neurology, 2023 - frontiersin.org
The glymphatic system is a highly specialized fluid transport system in the central nervous
system. It enables the exchange of the intercellular fluid of the brain, regulation of the …

Glymphatic MRI techniques in sleep and neurodegenerative diseases

H Lee, SH Choi, Y Anzai - Current Opinion in Pulmonary Medicine, 2022 - journals.lww.com
The glymphatic system plays a crucial role in clearing metabolic wastes in the brain.
Glymphatic MR imaging using GBCA administration serves as a functional imaging tool to …

[HTML][HTML] The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer's disease …

H Hong, L Hong, X Luo, Q Zeng, K Li, S Wang… - Alzheimer's Research & …, 2024 - Springer
Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer's disease
(AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common …

Longitudinal relationships between depressive symptoms and cognitive function after stroke: a cross-lagged panel design

W Liang, J Miao, Y Wang, W Sun, C Pan… - Journal of …, 2023 - Elsevier
Objective Stroke is a leading cause of mortality and disability. This study aimed to
investigate the temporal and directional relationships between post-stroke depressive …

p75NTR ectodomain ameliorates cognitive deficits and pathologies in a rapid eye movement sleep deprivation mice model

Y Zhu, M Gao, H Huang, SH Gao, LY Liao, Y Tao… - Neuroscience, 2022 - Elsevier
The neurotrophin receptor p75 (p75NTR) is a circadian rhythm regulator and mediates
cognitive deficits induced by sleep deprivation (SD). The soluble extracellular domain of …

[HTML][HTML] MRI-based demonstration of the normal glymphatic system in a human population: a systematic review

MK Lee, SJ Cho, YJ Bae, JM Kim - Frontiers in Neurology, 2022 - frontiersin.org
Background The glymphatic system has been described as one that facilitates the exchange
between the cerebrospinal fluid (CSF) and interstitial fluid, and many recent studies have …

Association between vascular risk factors and idiopathic normal pressure hydrocephalus: a Mendelian randomization study

Z Deng, H Wang, K Huang, Y Li, Y Ran, Y Chen… - Journal of …, 2023 - Springer
Background and objective Patients with idiopathic normal pressure hydrocephalus (iNPH)
have a higher prevalence of hypertension and diabetes. However, the causal effects of …

Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the …

Y Jin, W Zhang, M Yu, J Li, Y Du, W Wang, G Chen… - Sleep Medicine, 2024 - Elsevier
Background Chronic insomnia impairs the glymphatic system and may lead to cognitive
impairment and dementia in elderly population. The diffusion tensor image analysis along …

A “glympse” into neurodegeneration: Diffusion MRI and cerebrospinal fluid aquaporin‐4 for the assessment of glymphatic system in Alzheimer's disease and other …

L Sacchi, F D'Agata, C Campisi, M Arcaro… - Human Brain …, 2024 - Wiley Online Library
The glymphatic system (GS) is a whole‐brain perivascular network, consisting of three
compartments: the periarterial and perivenous spaces and the interposed brain …