In males, aging is accompanied by decline in serum testosterone levels due to impairment of
testicular Leydig cells. The polycomb protein BMI1 has recently been identified as an anti …

Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress
response. Although a great deal of work has been done on the neuropeptides and …

Chronic kidney disease (CKD) is frequently accompanied by reproductive health challenges
in females and males alike. Progression of CKD is associated with escalating impairment of …

Our present knowledge on interrelation between morphology/ultrastructure of mitochondria
of the Leydig cell and its steroidogenic function is far from satisfactory and needs additional …

The mechanisms of prenatal cadmium (Cd) exposure cause adverse effect transmission to
future generations that remain unclear. In this study, pregnant SD rats were orally dosed with …

We are all living with hundreds of anthropogenic chemicals in our bodies every day, a
situation that threatens the reproductive health of present and future generations. This …

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in a variety of
industrial processes and manufacturing of consumer products. Current efforts by the …

Abstract 17α-estradiol (17α-E2) is referred to as a nonfeminizing estrogen that was recently
found to extend healthspan and lifespan in male, but not female, mice. Despite an …

FOXP2 was initially characterized as a transcription factor linked to speech and language
disorders. Single-cell RNA sequencing reveals that Foxp2 is enriched in the gonadotrope …

Asprosin, a protein-based secretary product of white adipose tissue, stimulates appetite
hepatic glucose production. It crosses blood-brain barrier and stimulates appetite center and …