[HTML][HTML] A weight of evidence review of the genotoxicity of titanium dioxide (TiO2)

D Kirkland, MJ Aardema, RV Battersby… - Regulatory Toxicology …, 2022 - Elsevier
Titanium dioxide is a ubiquitous white material found in a diverse range of products from
foods to sunscreens, as a pigment and thickener, amongst other uses. Titanium dioxide has …

Titanium dioxide nanoparticle genotoxicity: A review of recent in vivo and in vitro studies

MR Wani, G Shadab - Toxicology and Industrial Health, 2020 - journals.sagepub.com
Titanium dioxide nanoparticles (TiO2 NPs, size< 100 nm) find applications in a wide range
of products including food and cosmetics. Studies have found that exposure to TiO2 NPs can …

Safety assessment of titanium dioxide (E171) as a food additive

EFSA Panel on Food Additives and Flavourings … - Efsa …, 2021 - Wiley Online Library
The present opinion deals with an updated safety assessment of the food additive titanium
dioxide (E 171) based on new relevant scientific evidence considered by the Panel to be …

[HTML][HTML] Adverse outcome pathways associated with the ingestion of titanium dioxide nanoparticles—a systematic review

D Rolo, R Assunção, C Ventura, P Alvito, L Gonçalves… - Nanomaterials, 2022 - mdpi.com
Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed
through food (E171), cosmetics (eg, toothpaste), and pharmaceuticals. The oral and …

Interactive effects of cadmium and titanium dioxide nanoparticles on hepatic tissue in rats: Ameliorative role of coenzyme 10 via modulation of the NF-κB and TNFα …

YM Abd-Elhakim, MMM Hashem… - Food and Chemical …, 2023 - Elsevier
This study investigated the effect of oral dosing of titanium dioxide nanoparticles (TNPs) and
cadmium (Cd 2+) on rat liver and the potential protective role of coenzyme Q10 (CQ10) …

[HTML][HTML] Gastrointestinal tract exposure to particles and DNA damage in animals: a review of studies before, during and after the peak of nanotoxicology

P Møller, M Roursgaard - Mutation Research/Reviews in Mutation …, 2024 - Elsevier
Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are
beneficial to health and food additives are considered safe. However, titanium dioxide …

[HTML][HTML] Cellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nanomaterials

A Vieira, A Gramacho, D Rolo, N Vital, MJ Silva… - Nanotoxicology in Safety …, 2022 - Springer
An exponential increase in products containing titanium dioxide nanomaterials (TiO2), in
agriculture, food and feed industry, lead to increased oral exposure to these nanomaterials …

[HTML][HTML] Toxicity spectrum and detrimental effects of titanium dioxide nanoparticles as an emerging pollutant: A review

Q Manzoor, A Sajid, Z Ali, A Nazir, A Sajid… - Desalination and Water …, 2024 - Elsevier
Titanium dioxide nanoparticles have wide industrial applications, due to their enhanced
mechanical, physical, optical and electric properties. TiO 2 based nanomaterials are …

[HTML][HTML] Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis

Y Cao, J Chen, Q Bian, J Ning, L Yong, T Ou, Y Song… - Toxics, 2023 - mdpi.com
Background: Recent studies have raised concerns about genotoxic effects associated with
titanium dioxide nanoparticles (TiO2 NPs), which are commonly used. This meta-analysis …

Hepatotoxicity of titanium dioxide nanoparticles

J Khan, ND Kim, C Bromhead, P Truman… - Journal of Applied …, 2024 - Wiley Online Library
The food additive E171 (titanium dioxide, TiO2), is widely used in foods, pharmaceuticals
and cosmetics. It is a fine white powder, with at least one third of its particles sized in the …