Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck
squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor …

Background The prognosis for patients with head and neck cancer (HNC) is poor and has
improved little in recent decades, partially due to lack of therapeutic options. To identify …

Background: Mammalian WD-repeat protein 12 (WDR12), a family member of proteins
containing repeats of tryptophan-aspartic acid (WD), is a potential homolog of yeast Ytm1p …

Tumors contain heterogeneous and dynamic populations of cells that do not all display the
fast-proliferating properties that traditional chemotherapies target. There is a need therefore …

Simple Summary Perineural invasion (PNI) as the fourth way for solid tumor metastasis and
invasion has attracted a lot of attention, and axon growth and possible nerve “invasion” to …

Heterogeneity is a characteristic feature of solid tumors. Intra-tumor heterogeneity includes
phenotypic diversity, epigenetic abnormalities, cell proliferation, and plasticity that eventually …

Abstract Cancer-associated fibroblasts (CAFs), a prominent component of the tumor
microenvironment, play an important role in tumor development, invasion, and drug …

The stromal elements of a malignant tumor can promote cancer progression and metastasis.
The structure of the tumor stroma includes connective tissue elements, blood vessels …

Aging is a natural intrinsic process associated with the loss of fibrous tissue, a slower cell
turnover, and a reduction in immune system competence. In the skin, the continuous …

In 2020, newly diagnosed breast cancer (BC) cases surpassed that of lung cancer among
women, making it the most common female cancer globally. In spite of recent increases in …