In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic l
form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of …

Background: Fourteen clinical trials have not shown a consistent benefit of combination
therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these …

The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …

The deiodinase family of enzymes mediates the activation and inactivation of thyroid
hormone. The role of these enzymes in the regulation of the systemic concentrations of …

Background: Approximately 15% more patients taking levothyroxine (LT4) report impaired
quality of life compared to controls. This could be explained by additional diagnoses …

Thyroid hormones (TH) are endocrine messengers essential for normal development and
function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely …

Context: Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism.
Objective: To determine whether LT4 at doses that normalize the serum TSH is associated …

Objective Dissatisfaction with treatment and impaired quality of life (QOL) are reported
among people with treated hypothyroidism. We aimed to gain insight into this. Design and …

Hypothyroidism is a common endocrinopathy, and levothyroxine is frequently prescribed.
Despite the basic tenets of initiating and adjusting levothyroxine being agreed on, there are …