Nearly 18 million people died from cardiovascular diseases in 2019, of these 85% were due
to heart attack and stroke. The available therapies although efficacious, have narrow …

Background Estrogen might play an important role in type 2 diabetes mellitus pathogenesis.
A number of polymorphisms have been reported in the estrogen receptor alpha (ERα) gene …

Epidemiological and experimental studies suggest a protective role of estrogens against
colorectal cancer. This effect seems to be mediated by their binding to estrogen receptor …

Thomas Hodgkin's (1796–1866) criteria for determining a cancer's malignancy would still
stand today: appearance of the tumor, tendency to spread, enlargement of neighboring …

Two oestrogen receptors (ERs), ERα and ERβ, have been identified. ERα is by far the better
characterized and is an established predictive marker in breast cancer which influences …

One in 10 men in the developed world will present with prostate cancer (CaP), and in an
ageing population developing strategies for its chemoprevention or treatment is of …

Oestrogen receptor (ER) is arguably the single most important biological predictive factor
that exists today. In the last 10 years or so, however, our understanding of ER biology has …

Alterations in the amino acid sequence of the estrogen receptor (ER) have been shown to
have dramatic effects on its function. Recently, mutant ERs have been isolated from both …

Plasma lipid profile is affected by endogenous estrogen levels and hormone replacement
therapy (HRT). As plasma lipid concentrations have a significant heritable basis and the …

BACKGROUND The etiology of hypospadias is regarded as a complex disorder with both
genetic and environmental contributions. Although alterations in androgen activity have …