Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine

S Fais, L O'Driscoll, FE Borras, E Buzas, G Camussi… - 2016 - ACS Publications
Recent research has demonstrated that all body fluids assessed contain substantial
amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by …

The emerging role of extracellular vesicles as biomarkers for urogenital cancers

M Nawaz, G Camussi, H Valadi, I Nazarenko… - Nature Reviews …, 2014 - nature.com
The knowledge gained from comprehensive profiling projects that aim to define the complex
genomic alterations present within cancers will undoubtedly improve our ability to detect and …

Bladder cancer diagnosis and follow-up: the current status and possible role of extracellular vesicles

E Oeyen, L Hoekx, S De Wachter, M Baldewijns… - International journal of …, 2019 - mdpi.com
Diagnostic methods currently used for bladder cancer are cystoscopy and urine cytology.
Cystoscopy is an invasive tool and has low sensitivity for carcinoma in situ. Urine cytology is …

Diagnostic and therapeutic potential of exosomes in cancer: the beginning of a new tale?

H Mirzaei, A Sahebkar, MR Jaafari… - Journal of cellular …, 2017 - Wiley Online Library
Exosomes have emerged as one of the main players in intercellular communication. These
small nano‐sized particles have many roles in various physiological pathways in normal …

Different EV enrichment methods suitable for clinical settings yield different subpopulations of urinary extracellular vesicles from human samples

F Royo, P Zuñiga-Garcia… - Journal of …, 2016 - Taylor & Francis
Urine sample analysis is irreplaceable as a non-invasive method for disease diagnosis and
follow-up. However, in urine samples, non-degraded protein and RNA may be only found in …

Urinary extracellular vesicles as source of biomarkers in kidney diseases

A Gámez-Valero, SI Lozano-Ramos, I Bancu… - Frontiers in …, 2015 - frontiersin.org
Most cells physiologically release vesicles as way of intercellular communication. The so-
called Extracellular Vesicles (EVs) include exosomes, ectosomes, and apoptotic bodies …

Urinary exosomes: the potential for biomarker utility, intercellular signaling and therapeutics in urological malignancy

CA Franzen, RH Blackwell, KE Foreman… - The Journal of …, 2016 - auajournals.org
Purpose: Exosomes are small secreted vesicles that contain proteins, mRNA and miRNA
with the potential to alter signaling pathways in recipient cells. While exosome research has …

Urinary biomarkers in bladder cancer: where do we stand and potential role of extracellular vesicles

MC Oliveira, HR Caires, MJ Oliveira, A Fraga… - Cancers, 2020 - mdpi.com
Extracellular vesicles (EVs) are small membrane vesicles released by all cells and involved
in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and …

Methods for extracellular vesicles isolation in a hospital setting

M Sáenz-Cuesta, A Arbelaiz, A Oregi, H Irizar… - Frontiers in …, 2015 - frontiersin.org
The research in extracellular vesicles (EVs) has been rising during the last decade.
However, there is no clear consensus on the most accurate protocol to isolate and analyze …

Exosomes: a novel strategy for treatment and prevention of diseases

J Wang, X Sun, J Zhao, Y Yang, X Cai, J Xu… - Frontiers in …, 2017 - frontiersin.org
An “exosome” is a nanoscale membrane vesicle derived from cell endocytosis that functions
as an important intercellular communication mediator regulating the exchange of proteins …