Numerous light-based diagnostic and therapeutic devices are routinely used in the clinic.
These devices have a familiar look as items plugged in the wall or placed at patients' …

Optogenetic tools have provided a new way to establish causal relationships between brain
activity and behaviour in health and disease. Although no animal model captures human …

We develop soft and stretchable fatigue-resistant hydrogel optical fibers that enable
optogenetic modulation of peripheral nerves in naturally behaving animals during persistent …

Deciding when and whether to move is critical for survival. Loss of dopamine neurons
(DANs) of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease …

Learning-related changes in brain activity are thought to underlie adaptive behaviours,. For
instance, the learning of a reward site by rodents requires the development of an over …

Optogenetics allows rapid, temporally specific control of neuronal activity by targeted
expression and activation of light-sensitive proteins. Implementation typically requires …

Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation
of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent …

In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits
implicated in neuropsychiatric disorders. Conventional hardware for such studies, however …

The prefrontal cortex is a critical neuroanatomical hub for controlling motivated behaviours
across mammalian species,,. In addition to intra-cortical connectivity, prefrontal projection …

CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to
block axonal regeneration, resulting in permanent functional deficits. We report that …