Candidate genes for type 2 diabetes
About 150 million people suffer from type 2 diabetes in the world today and it has been
predicted that this number will be doubled within 15 years [1]. It is no longer a disease of the …
predicted that this number will be doubled within 15 years [1]. It is no longer a disease of the …
[HTML][HTML] TNF-alpha− 308G/A and− 238G/A polymorphisms and its protein network associated with type 2 diabetes mellitus
K Jamil, A Jayaraman, J Ahmad, S Joshi… - Saudi Journal of …, 2017 - Elsevier
Several reports document the role of tumor necrosis factor alpha (TNF-α) and lipid
metabolism in the context of acute inflammation as a causative factor in obesity-associated …
metabolism in the context of acute inflammation as a causative factor in obesity-associated …
Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated …
OBJECTIVE: Mice lacking the tumor necrosis factor-alpha receptor 2 (TNFR2) gene fed a
high-fat diet gain less weight and display reduced leptin and insulin levels. In humans …
high-fat diet gain less weight and display reduced leptin and insulin levels. In humans …
Tumor necrosis factor-α− 308 G/A polymorphism in obese Caucasians
E Brand, U Schorr, I Kunz, E Kertmen… - International journal of …, 2001 - nature.com
OBJECTIVE: Tumor necrosis factor-α (TNF-α) is expressed primarily in adipocytes, and
elevated levels of this cytokine have been linked to obesity and insulin resistance. Recently …
elevated levels of this cytokine have been linked to obesity and insulin resistance. Recently …
Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene …
H Hohjoh, K Tokunaga - Genes & Immunity, 2001 - nature.com
The tumor necrosis factor-alpha gene (TNFA) is characterized by several single nucleotide
polymorphisms (SNPs) in its promoter region. Interestingly, some of these SNPs appear to …
polymorphisms (SNPs) in its promoter region. Interestingly, some of these SNPs appear to …
Inflammation and atherosclerosis: the role of TNF and TNF receptors polymorphisms in coronary artery disease
I Sbarsi, C Falcone, C Boiocchi… - International …, 2007 - journals.sagepub.com
Inflammation plays an important role in the pathogenesis of atherosclerosis and coronary
syndromes; moreover, various lines of evidence suggest that genetic factors contribute …
syndromes; moreover, various lines of evidence suggest that genetic factors contribute …
The human obesity gene map: the 1998 update
L Pérusse, YC Chagnon, J Weisnagel… - Obesity …, 1999 - Wiley Online Library
Abstract PÉRUSSE, LOUIS, YVON C. CHAGNON, JOHN WEISNAGEL, AND CLAUDE
BOUCHARD. The human obesity gene map: the 1998 update. Obes Res. 1999; 7: 111–129 …
BOUCHARD. The human obesity gene map: the 1998 update. Obes Res. 1999; 7: 111–129 …
Metabolic complications of obesity: Pathophysiologic considerations
MT Sheehan, MD Jensen - Medical Clinics of North America, 2000 - Elsevier
Obesity has long been recognized as contributing to a variety of adverse health
consequences. Despite the growing body of evidence of these risks, the prevalence of …
consequences. Despite the growing body of evidence of these risks, the prevalence of …
[PDF][PDF] Non-alcoholic fatty liver disease: treatment options based on pathogenic considerations
CM Oneta - Swiss medical weekly, 2002 - smw.ch
NASH is a frequent liver disease that develops in close association with IR and may
progress to cirrhosis. Exclusion of excessive alcohol consumption as well as of other liver …
progress to cirrhosis. Exclusion of excessive alcohol consumption as well as of other liver …
Tumor necrosis factor-alpha-238 and-308 polymorphisms do not associated with traits related to obesity and insulin resistance.
J Walston, M Seibert, CJ Yen, LJ Cheskin… - Diabetes, 1999 - Am Diabetes Assoc
Tumor necrosis factor-alpha (TNF-alpha) is expressed primarily in adipocytes, and elevated
levels of this cytokine have been linked to obesity and insulin resistance. The purpose of this …
levels of this cytokine have been linked to obesity and insulin resistance. The purpose of this …