Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …

Advances in vertebrate genomics have uncovered thousands of loci encoding long
noncoding RNAs (lncRNAs). While progress has been made in elucidating the regulatory …

We have conducted a comprehensive search for conserved elements in vertebrate
genomes, using genome-wide multiple alignments of five vertebrate species (human …

A recent slew of ENCyclopedia Of DNA Elements (ENCODE) Consortium publications,
specifically the article signed by all Consortium members, put forward the idea that more …

Multicellular eukaryotic genomes show enormous differences in size. A substantial part of
this variation is due to the presence of transposable elements (TEs). They contribute …

Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the
expression and mobility of transposable elements (TEs). Owing to their ability to recruit the …

The control and coordination of eukaryotic gene expression rely on transcriptional and post-
transcriptional regulatory networks. Although progress has been made in mapping the …

Comparisons of orthologous genomic DNA sequences can be used to characterize regions
that have been subject to purifying selection and are enriched for functional elements. We …

Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …