During oxidative phosphorylation, mitochondria continuously produce reactive oxygen
species (ROS), and untimely ROS clearance can subject mitochondria to oxidative stress …

Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox
system, encompassing pro-oxidative proteins and antioxidative proteins. These proteins …

Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a
primary catalyst for microcirculation dysfunction and enterogenous infection. Previous …

Recent evidence shows a close link between Parkinson's disease (PD) and cardiac
dysfunction with limited treatment options. Mitophagy plays a crucial role in the control of …

Programmed cell death (PCD) is a comprehensive term that encompasses various forms of
cell death, such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy, which …

Septic cardiomyopathy is one of the predominant culprit factors contributing to the rising
mortality in patients with severe sepsis. Among various mechanisms responsible for the …

Background Doxorubicin (DOX) is a chemotherapeutic drug, while its clinical use is greatly
limited by the life-threatening cardiotoxicity. N 6-methyladenosine (m 6 A) RNA modification …

Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in
diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects …

Osteoarthritis (OA) is a prevalent degenerative disease of the elderly. The NRF2 antioxidant
system plays a critical role in maintaining redox balance. Mitoquinone (MitoQ) is a …

Ferroptosis is a distinctive form of iron-dependent cell death characterized by significant
ultrastructural changes in mitochondria. Given the crucial involvement of mitochondria in …