[HTML][HTML] Guidelines for regulated cell death assays: a systematic summary, a categorical comparison, a prospective

X Hu, Z Li, R Lin, J Shan, Q Yu, R Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Over the past few years, the field of regulated cell death continues to expand and novel
mechanisms that orchestrate multiple regulated cell death pathways are being unveiled …

Oxidative Stress‐Mediated Blood‐Brain Barrier (BBB) Disruption in Neurological Diseases

K Song, Y Li, H Zhang, N An, Y Wei… - Oxidative medicine …, 2020 - Wiley Online Library
The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling

S Xu, J Wang, J Zhong, M Shao, J Jiang… - Clinical and …, 2021 - Wiley Online Library
Background Neuroinflammation‐induced secondary injury is an important cause of
sustained progression of spinal cord injury. Inflammatory programmed cell death pyroptosis …

Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis

T Rui, H Wang, Q Li, Y Cheng, Y Gao… - Journal of Pineal …, 2021 - Wiley Online Library
Accumulating evidence demonstrates that ferroptosis may be important in the
pathophysiological process of traumatic brain injury (TBI). As a major hormone of the pineal …

[HTML][HTML] Bibliometric analysis of the inflammasome and pyroptosis in brain

Y Chen, Y Li, L Guo, J Hong, W Zhao, X Hu… - Frontiers in …, 2021 - frontiersin.org
Background: Considering the pivotal role of inflammasome/pyroptosis in biological function,
we visually analyzed the research hotspots of inflammasome/pyroptosis related to the brain …

Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …

[HTML][HTML] Revisiting excitotoxicity in traumatic brain injury: from bench to bedside

D Baracaldo-Santamaría, DF Ariza-Salamanca… - Pharmaceutics, 2022 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality.
Consequences vary from mild cognitive impairment to death and, no matter the severity of …

[HTML][HTML] Surface-fill H2S-releasing silk fibroin hydrogel for brain repair through the repression of neuronal pyroptosis

X Chen, X Huang, C Liu, S Li, Z Yang, F Zhang… - Acta Biomaterialia, 2022 - Elsevier
Traumatic brain injury (TBI) remains the major cause of disability and mortality worldwide
due to the persistent neuroinflammation and neuronal death induced by TBI. Among them …

[HTML][HTML] Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage

B Yuan, X Zhou, Z You, W Xu, J Fan, S Chen… - Cell Death & …, 2020 - nature.com
Only a few types of inflammasomes have been described in central nervous system cells.
Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in …

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

X Ge, W Li, S Huang, Z Yin, X Xu, F Chen, X Kong… - Brain research, 2018 - Elsevier
Pyroptosis is a highly specific type of inflammatory programmed cell death that different from
necrosis or apoptosis. It is initiated by cellular detection of acute damage via recognizing …