Oseltamivir (Tamiflu®) and its potential for use in the event of an influenza pandemic

P Ward, I Small, J Smith, P Suter… - Journal of Antimicrobial …, 2005 - academic.oup.com
Recent cross species transmission of avian influenza has highlighted the threat of pandemic
influenza. Oseltamivir (Tamiflu®) has been shown to be effective in the treatment and …

Put a cork in it: Plugging the M2 viral ion channel to sink influenza

PH Jalily, MC Duncan, D Fedida, J Wang, I Tietjen - Antiviral research, 2020 - Elsevier
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals
that can effectively supplement existing vaccination strategies. The M2 protein of influenza A …

[HTML][HTML] Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

GJD Smith, D Vijaykrishna, J Bahl, SJ Lycett… - Nature, 2009 - nature.com
Abstract In March and early April 2009, a new swine-origin influenza A (H1N1) virus (S-OIV)
emerged in Mexico and the United States. During the first few weeks of surveillance, the …

Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia

KS Li, Y Guan, J Wang, GJD Smith, KM Xu, L Duan… - Nature, 2004 - nature.com
A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in
China and seven other east Asian countries between late 2003 and early 2004; the same …

[HTML][HTML] Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

TL Toft-Bertelsen, MG Jeppesen, E Tzortzini… - Communications …, 2021 - nature.com
The dire need for COVID-19 treatments has inspired strategies of repurposing approved
drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical …

Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control

H Chen, GJD Smith, KS Li, J Wang… - Proceedings of the …, 2006 - National Acad Sciences
Preparedness for a possible influenza pandemic caused by highly pathogenic avian
influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe …

H5N1 influenza: a protean pandemic threat

Y Guan, LLM Poon, CY Cheung… - Proceedings of the …, 2004 - National Acad Sciences
Infection with avian influenza A virus of the H5N1 subtype (isolates A/HK/212/03 and
A/HK/213/03) was fatal to one of two members of a family in southern China in 2003. This …

Emergence and predominance of an H5N1 influenza variant in China

GJD Smith, XH Fan, J Wang, KS Li… - Proceedings of the …, 2006 - National Acad Sciences
The development of highly pathogenic avian H5N1 influenza viruses in poultry in Eurasia
accompanied with the increase in human infection in 2006 suggests that the virus has not …

[HTML][HTML] Evolutionary pathway analysis and unified classification of East Asian lineage of Mycobacterium tuberculosis

E Shitikov, S Kolchenko, I Mokrousov, J Bespyatykh… - Scientific reports, 2017 - nature.com
Due to its rapid spread and association with the numerous outbreaks, the global spread of
East Asian lineage of Mycobacterium tuberculosis strains presents a global concern …

Distribution of amantadine-resistant H5N1 avian influenza variants in Asia

CL Cheung, JM Rayner, GJD Smith… - Journal of Infectious …, 2006 - academic.oup.com
We examined the distribution of genetic mutations associated with resistance to the M2 ion
channel–blocking adamantane derivatives, amantadine and rimantadine, among H5N1 …