Integrins as a drug target in liver fibrosis
As the worldwide prevalence of chronic liver diseases is high and continuing to increase,
there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality …
there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality …
αv integrins: key regulators of tissue fibrosis
KP Conroy, LJ Kitto, NC Henderson - Cell and tissue research, 2016 - Springer
Chronic tissue injury with fibrosis results in the disruption of tissue architecture, organ
dysfunction and eventual organ failure. Therefore, the development of effective anti-fibrotic …
dysfunction and eventual organ failure. Therefore, the development of effective anti-fibrotic …
Liver matrix in benign and malignant biliary tract disease
L Fabris, M Cadamuro, S Cagnin… - Seminars in liver …, 2020 - thieme-connect.com
The extracellular matrix is a highly reactive scaffold formed by a wide array of multifunctional
molecules, encompassing collagens and noncollagenous glycoproteins, proteoglycans …
molecules, encompassing collagens and noncollagenous glycoproteins, proteoglycans …
Recent progress in the molecular imaging of nonalcoholic fatty liver disease
O Wegrzyniak, M Rosestedt, O Eriksson - International Journal of …, 2021 - mdpi.com
Pathological fibrosis of the liver is a landmark feature in chronic liver diseases, including
nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) …
nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) …
Integrin β8 facilitates tumor growth and drug resistance through a Y‐box binding protein 1‐dependent signaling pathway in bladder cancer
S Liu, L Chen, H Zhao, Q Li, R Hu, H Wang - Cancer Science, 2020 - Wiley Online Library
The transmembrane receptors integrins are the bridges for cell‐cell or cell‐ECM interaction,
which is strictly correlated to cancer development in several tumor types. Here, we revealed …
which is strictly correlated to cancer development in several tumor types. Here, we revealed …
TGF-β1, Smad2 在胆道闭锁肝纤维化中的作用.
丁美云， 詹江华， 赵丽， 赵林胜… - Tianjin Medical …, 2016 - search.ebscohost.com
目的研究转化生长因子(TGF)-β1 与Smad2 蛋白在胆道闭锁(BA) 肝组织中的表达情况及在肝
纤维化进程中的作用. 方法选取2010 年1 月—2014 年7 月尸检(患儿死于非肝胆疾病 …
纤维化进程中的作用. 方法选取2010 年1 月—2014 年7 月尸检(患儿死于非肝胆疾病 …
整合素αvβ8, p38 及ERK1/2 在胆道闭锁患儿肝脏中的表达及意义.
高婷， 詹江华， 丁美云， 卫园园 - Tianjin Medical Journal, 2016 - search.ebscohost.com
目的研究转化生长因子(TGF)-β1 通路相关调节蛋白整合素αvβ8, p38 及细胞外调节蛋白激酶1/2
(ERK1/2) 蛋白在胆道闭锁(BA) 患儿肝脏中的表达情况及在肝纤维化进程中的作用 …
(ERK1/2) 蛋白在胆道闭锁(BA) 患儿肝脏中的表达情况及在肝纤维化进程中的作用 …
Toll-like receptor 3 mediates PROMININ-1 expressing cell expansion in biliary atresia via Transforming Growth Factor-Beta
JA Zagory, MV Nguyen, W Dietz, N Mavila… - Journal of pediatric …, 2016 - Elsevier
Background In biliary atresia (BA), epithelial-mesenchymal hepatic progenitor cells (HPC)
expressing the stem/progenitor cell marker PROMININ-1 (PROM1) undergo expansion and …
expressing the stem/progenitor cell marker PROMININ-1 (PROM1) undergo expansion and …
Investigation of the role of hepatic stellate cells in acute liver failure and hepatocarcinogenesis
AI Thompson - 2017 - era.ed.ac.uk
Introduction: Hepatic stellate cells (HSC) and myofibroblasts may be relevant stromal drivers
of human hepatocellular carcinoma (HCC). It was hypothesised that targeted inhibition of αv …
of human hepatocellular carcinoma (HCC). It was hypothesised that targeted inhibition of αv …
Hepatic expression of integrin β-8 protein as a risk factor in infants with biliary atresia
MA Khedr, NM Adawy, BE Behairy… - Alexandria Journal of …, 2019 - journals.lww.com
Hepatic expression of integrin β-8 protein as a risk factor... : Alexandria Journal of Pediatrics
Hepatic expression of integrin β-8 protein as a risk factor in infants with biliary atresia …
Hepatic expression of integrin β-8 protein as a risk factor in infants with biliary atresia …