Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated in the
etiology of numerous human diseases. Oxidative/Nitrosative stress is the result of an …

BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …

The notion that electrophiles serve as messengers in cell signaling is now widely accepted.
Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as …

We present arguments for an evolution in our understanding of how antioxidants in fruits and
vegetables exert their health-protective effects. There is much epidemiological evidence for …

Nrf2: INrf2 (Keap1) are cellular sensors of chemical-and radiation-induced oxidative and
electrophilic stress. Nrf2 is a nuclear transcription factor that controls the expression and …

The Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2])–Keap1 (Kelch-like
erythroid cell-derived protein with CNC homology [ECH]-associated protein 1) signaling …

Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis.
Numerous phytochemicals derived from edible plants have been reported to interfere with a …

Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …

The brain is a metabolically active organ exhibiting high oxygen consumption and robust
production of reactive oxygen species (ROS). The large amounts of ROS are kept in check …