Macrophages are phagocytic cells that produce and release reactive oxygen species (ROS)
in response to phagocytosis or stimulation with various agents. The enzyme responsible for …

Mitochondrial respiration results in an electrochemical proton gradient, or protonmotive force
(pmf), across the mitochondrial inner membrane. The pmf is a form of potential energy …

Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert
beneficial effects on the central nervous system by protecting neurons against stress …

The antioxidant response element (ARE) and transcription factor Nrf2 regulate basal
expression and antioxidant induction of NAD (P) H: quinone oxidoreductase-1 (NQO1) and …

NQO1 [NAD (P) H: quinone oxidoreductase 1] has an integral role in cellular responses to
oxidative stress. The expression of NQO1 is up-regulated in the mouse following challenge …

Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …

The antioxidant response element (ARE) and Nrf2 are known to regulate the expression and
coordinated induction of genes encoding detoxifying enzymes including NAD (P) H: quinone …

Nrf2, a redox sensitive transcription factor, plays a pivotal role in redox homeostasis during
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …

Nrf2 mediates inducer-dependent activation of the heme oxygenase-1 (HO-1) gene (Alam,
J., Stewart, D., Touchard, C., Boinapally, S., Choi, AM, and Cook, JL (1999) J. Biol. Chem …

The induction of many antioxidant and phase II drug-metabolizing enzymes by phenolic
antioxidants and electrophilic compounds is regulated at the transcriptional level. The …