Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
This article provides an overview of the mechanisms by which cancer chemopreventive
blocking agents increase the expression of detoxication and antioxidant genes. These …
blocking agents increase the expression of detoxication and antioxidant genes. These …
Reactive oxygen species, cancer and anti-cancer therapies
G Manda, MT Nechifor, TM Neagu - Current Chemical Biology, 2009 - ingentaconnect.com
Mammalian cells produce reactive oxygen species (ROS) which are carcinogens, key actors
of the non-specific immune defense against pathogens and, in a more subtle way, of signal …
of the non-specific immune defense against pathogens and, in a more subtle way, of signal …
Modulation of oxidative stress and mitochondrial function by the ketogenic diet
The ketogenic diet (KD) is a high-fat, low carbohydrate diet that is used as a therapy for
intractable epilepsy. However, the mechanism (s) by which the KD achieves neuroprotection …
intractable epilepsy. However, the mechanism (s) by which the KD achieves neuroprotection …
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD (P) H: quinone oxidoreductase1 …
S Dhakshinamoorthy, AK Jaiswal - Oncogene, 2001 - nature.com
Antioxidant response element (ARE) and nuclear transcription factor Nrf2 are known to
regulate expression and coordinated induction of NQO1 and other detoxifying enzyme …
regulate expression and coordinated induction of NQO1 and other detoxifying enzyme …
[HTML][HTML] Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
AY Shih, S Imbeault, V Barakauskas, H Erb… - Journal of Biological …, 2005 - ASBMB
NF-E2 related factor (Nrf2) controls a pleiotropic cellular defense, where multiple
antioxidant/detoxification pathways are up-regulated in unison. Although small molecule …
antioxidant/detoxification pathways are up-regulated in unison. Although small molecule …
Redox control systems in the nucleus: mechanisms and functions
Proteins with oxidizable thiols are essential to many functions of cell nuclei, including
transcription, chromatin stability, nuclear protein import and export, and DNA replication and …
transcription, chromatin stability, nuclear protein import and export, and DNA replication and …
The Nrf2/ARE pathway: a promising target to counteract mitochondrial dysfunction in Parkinson′ s disease
KU Tufekci, E Civi Bayin, S Genc… - Parkinson's disease, 2011 - Wiley Online Library
Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases as
strict regulation of integrated mitochondrial functions is essential for neuronal signaling …
strict regulation of integrated mitochondrial functions is essential for neuronal signaling …
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (−/−) mice
R Hu, C Xu, G Shen, MR Jain, TO Khor… - Cancer letters, 2006 - Elsevier
Sulforaphane (SFN) is a potent and promising naturally occurring dietary cancer
chemopreventive compound that exerts its cancer protective effects by the induction of …
chemopreventive compound that exerts its cancer protective effects by the induction of …
Thioredoxin and its role in toxicology
WH Watson, X Yang, YE Choi, DP Jones… - Toxicological …, 2004 - academic.oup.com
Thioredoxins (Trx) are members of an evolutionarily conserved family of redox-active
proteins containing a conserved active site dithiol motif. Trx supports diverse reduction …
proteins containing a conserved active site dithiol motif. Trx supports diverse reduction …
Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function
MJ Jackson, S Papa, J Bolaños, R Bruckdorfer… - Molecular aspects of …, 2002 - Elsevier
There has been increasing interest, in recent years, in the possibility that reactive
oxygen/nitrogen species (ROS/RNS) act as signals, or mediators of changes, in cell function …
oxygen/nitrogen species (ROS/RNS) act as signals, or mediators of changes, in cell function …