This article provides an overview of the mechanisms by which cancer chemopreventive
blocking agents increase the expression of detoxication and antioxidant genes. These …

Mammalian cells produce reactive oxygen species (ROS) which are carcinogens, key actors
of the non-specific immune defense against pathogens and, in a more subtle way, of signal …

The ketogenic diet (KD) is a high-fat, low carbohydrate diet that is used as a therapy for
intractable epilepsy. However, the mechanism (s) by which the KD achieves neuroprotection …

Antioxidant response element (ARE) and nuclear transcription factor Nrf2 are known to
regulate expression and coordinated induction of NQO1 and other detoxifying enzyme …

NF-E2 related factor (Nrf2) controls a pleiotropic cellular defense, where multiple
antioxidant/detoxification pathways are up-regulated in unison. Although small molecule …

Proteins with oxidizable thiols are essential to many functions of cell nuclei, including
transcription, chromatin stability, nuclear protein import and export, and DNA replication and …

Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases as
strict regulation of integrated mitochondrial functions is essential for neuronal signaling …

Sulforaphane (SFN) is a potent and promising naturally occurring dietary cancer
chemopreventive compound that exerts its cancer protective effects by the induction of …

Thioredoxins (Trx) are members of an evolutionarily conserved family of redox-active
proteins containing a conserved active site dithiol motif. Trx supports diverse reduction …

There has been increasing interest, in recent years, in the possibility that reactive
oxygen/nitrogen species (ROS/RNS) act as signals, or mediators of changes, in cell function …