Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

[HTML][HTML] Antioxidant therapy in cancer: Rationale and progress

M Luo, L Zhou, Z Huang, B Li, EC Nice, J Xu, C Huang - Antioxidants, 2022 - mdpi.com
Cancer is characterized by increased oxidative stress, an imbalance between reactive
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …

Catalytically Active CoFe2O4 Nanoflowers for Augmented Sonodynamic and Chemodynamic Combination Therapy with Elicitation of Robust Immune Response

S Fu, R Yang, J Ren, J Liu, L Zhang, Z Xu, Y Kang… - Acs Nano, 2021 - ACS Publications
A hypoxic and acidic tumor microenvironment (TME) plays a significant role in cancer
development through complex cellular signaling networks, and it is thus challenging to …

Activatable NIR‐II plasmonic nanotheranostics for efficient photoacoustic imaging and photothermal cancer therapy

C Zhou, L Zhang, T Sun, Y Zhang, Y Liu… - Advanced …, 2021 - Wiley Online Library
Precise manipulation of optical properties through the structure‐evolution of plasmonic
nanoparticles is of great interest in biomedical fields including bioimaging and phototherapy …

[HTML][HTML] Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

V Gandin, P Khalkar, J Braude… - Free Radical Biology and …, 2018 - Elsevier
Selenium (Se)-containing compounds have attracted a growing interest as anticancer
agents over recent decades, with mounting reports demonstrating their high efficacy and …

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

J Zhang, D Duan, ZL Song, T Liu… - Medicinal Research …, 2021 - Wiley Online Library
Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Emerging therapies in cancer metabolism

Y Xiao, TJ Yu, Y Xu, R Ding, YP Wang, YZ Jiang… - Cell Metabolism, 2023 - cell.com
Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Free radicals and oxidative stress: signaling mechanisms, redox basis for human diseases, and cell cycle regulation

IZ Sadiq - Current molecular medicine, 2023 - ingentaconnect.com
Free radicals contain one or more unpaired electrons in their valence shell, thus making
them unstable, short-lived, and highly reactive species. Excessive generation of these free …

Metabolic reprogramming in anticancer drug resistance: a focus on amino acids

E Pranzini, E Pardella, P Paoli, SM Fendt, ML Taddei - Trends in Cancer, 2021 - cell.com
Overcoming anticancer drug resistance is a major challenge in cancer therapy, requiring
innovative strategies that consider the extensive tumor heterogeneity and adaptability. We …

[HTML][HTML] Targeting lipid peroxidation for cancer treatment

SM Clemente, OH Martínez-Costa, M Monsalve… - Molecules, 2020 - mdpi.com
Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer
and its prognosis are very dependent on the affected tissue, body location, and stage at …