Tripartite motif containing-21 (TRIM21), an E3 ubiquitin ligase, was initially found to be
involved in antiviral responses and autoimmune diseases. Recently studies have reported …

The tripartite motif protein 21 (TRIM21) belongs to the TRIM family, possessing an E3
ubiquitin ligase activity. Similar to other TRIMs, TRIM21 also contains three domains (named …

The innate immune response is the first line of host defense against viral infections, but its
role in immunity against SARS‐CoV‐2 remains unclear. By using immunoprecipitation …

Hepatitis B, a global health concern caused by the hepatitis B virus (HBV), infects nearly 2
billion individuals worldwide, as reported by the World Health Organization (WHO). HBV, a …

Growing evidences have demonstrated that multiple TRIM (tripartite motif) proteins exert
critical roles in host defense against different microbial pathogens. Although mammalian …

African swine fever (ASF) is a highly contagious lethal viral disease in pigs caused by the
African swine fever virus (ASFV), which has greatly threatened Chinese animal health and …

Hepatitis B virus (HBV) infection affects hepatic metabolism. Serum metabolomics studies
have suggested that HBV possibly hijacks the glycerol-3-phosphate (G3P) shuttle. In this …

Background: The hepatitis B virus (HBV) vaccine has been efficiently used for decades.
However, hepatocellular carcinoma caused by HBV is still prevalent globally. We previously …

Hepatitis B virus (HBV) infection is a major public health problem worldwide, causing nearly
one million deaths annually. OTUD5 is a deubiquitinase associated with cancer …

Hepatitis B virus (HBV) infection is one of main contributors to poor prognosis and rapid
progression of hepatocellular cancer (HCC). We previously identified the important role of …