[HTML][HTML] Deep brain stimulation beyond the clinic: Navigating the future of Parkinson's and Alzheimer's disease therapy

DKL Senevirathne, A Mahboob, K Zhai, P Paul… - Cells, 2023 - mdpi.com
Deep brain stimulation (DBS) is a surgical procedure that uses electrical neuromodulation to
target specific regions of the brain, showing potential in the treatment of neurodegenerative …

[HTML][HTML] Tremor in Parkinson's disease: from pathophysiology to advanced therapies

AH Abusrair, W Elsekaily, S Bohlega - Tremor and Other …, 2022 - ncbi.nlm.nih.gov
Background: Tremor is one of the most prevalent symptoms in Parkinson's Disease (PD).
The progression and management of tremor in PD can be challenging, as response to …

The role of levodopa challenge in predicting the outcome of subthalamic deep brain stimulation

R Wolke, JS Becktepe, S Paschen… - Movement disorders …, 2023 - Wiley Online Library
Background Deep brain stimulation of the subthalamic nucleus (STN‐DBS) is an effective
and evidence‐based treatment for idiopathic Parkinson's disease (iPD). A minority of …

Preoperative levodopa response and deep brain stimulation effects on motor outcomes in Parkinson's disease: a systematic review

Z Lin, C Zhang, D Li, B Sun - Movement Disorders Clinical …, 2022 - Wiley Online Library
Background The up‐to‐date literature systematically reviewing the predictive value of
preoperative levodopa responsiveness after deep brain stimulation (DBS) surgery in motor …

Dissecting the domains of Parkinson's disease: insights from longitudinal item response theory modeling

S Luo, H Zou, GT Stebbins… - Movement …, 2022 - Wiley Online Library
Background Longitudinal item response theory (IRT) models previously suggested that the
Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) motor …

[HTML][HTML] Clinical factors and dopamine transporter availability for the prediction of outcomes after globus pallidus deep brain stimulation in Parkinson's disease

SH Lee, M Kim, J Lee, JW Kim, MS Kim, S Jo… - Scientific reports, 2022 - nature.com
We aimed to investigate the predictive value of preoperative clinical factors and dopamine
transporter imaging for outcomes after globus pallidus interna (GPi) deep brain stimulation …

[HTML][HTML] Long-term safety and efficacy of frameless subthalamic deep brain stimulation in Parkinson's disease

D Genovese, F Bove, L Rigon, T Tufo, A Izzo… - Neurological …, 2024 - Springer
Background Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is
standard of care for Parkinson's disease (PD) patients and a correct lead placement is …

[HTML][HTML] Rescue subthalamic stimulation after unsatisfactory outcome of pallidal stimulation in Parkinson's disease: a case series and review

Z Zeng, P Huang, Z Lin, Y Pan, X Wan… - Frontiers in Aging …, 2024 - frontiersin.org
Background Subthalamic nucleus (STN) and globus pallidus interna (GPi) are two main
structures primarily targeted by deep brain stimulation (DBS) to treat advanced Parkinson's …

[HTML][HTML] Premature drug reduction after subthalamic nucleus deep brain stimulation leading to worse depression in patients with Parkinson's disease

Y Diao, T Hu, H Xie, H Fan, F Meng, A Yang… - Frontiers in …, 2023 - frontiersin.org
Background Reduction of medication in Parkinson's disease (PD) following subthalamic
nucleus deep brain stimulation (STN-DBS) has been recognized, but the optimal timing for …

[HTML][HTML] High cervical spinal cord stimulation in Parkinson's disease with dopamine-resistant axial disabilities: a case with 2-year follow-up

Z Lin, L Wang, P Huang, Y Pan, Y Tan, S Chen… - Journal of Neurology, 2023 - Springer
The management of disabling axial disabilities in advanced Parkinson's disease (PD) is
challenging since they are frequently insensitive to pharmacotherapy and deep brain …