A reference cell tree will serve science better than a reference cell atlas
S Domcke, J Shendure - Cell, 2023 - cell.com
Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …
The origin and evolution of cell types
Cell types are the basic building blocks of multicellular organisms and are extensively
diversified in animals. Despite recent advances in characterizing cell types, classification …
diversified in animals. Despite recent advances in characterizing cell types, classification …
[HTML][HTML] Single-cell RNA-seq analysis of retinal development identifies NFI factors as regulating mitotic exit and late-born cell specification
Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …
The types of retinal ganglion cells: current status and implications for neuronal classification
JR Sanes, RH Masland - Annual review of neuroscience, 2015 - annualreviews.org
In the retina, photoreceptors pass visual information to interneurons, which process it and
pass it to retinal ganglion cells (RGCs). Axons of RGCs then travel through the optic nerve …
pass it to retinal ganglion cells (RGCs). Axons of RGCs then travel through the optic nerve …
Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
J Liu, D Ottaviani, M Sefta, C Desbrousses… - Nature …, 2021 - nature.com
Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the developing retina. Little is known on the molecular basis …
maturing cone precursor in the developing retina. Little is known on the molecular basis …
[HTML][HTML] Retinal organoids from pluripotent stem cells efficiently recapitulate retinogenesis
M Völkner, M Zschätzsch, M Rostovskaya, RW Overall… - Stem cell reports, 2016 - cell.com
The plasticity of pluripotent stem cells provides new possibilities for studying development,
degeneration, and regeneration. Protocols for the differentiation of retinal organoids from …
degeneration, and regeneration. Protocols for the differentiation of retinal organoids from …
Molecular anatomy of the developing human retina
Clinical and genetic heterogeneity associated with retinal diseases makes stem-cell-based
therapies an attractive strategy for personalized medicine. However, we have limited …
therapies an attractive strategy for personalized medicine. However, we have limited …
[HTML][HTML] Stemming retinal regeneration with pluripotent stem cells
ZB Jin, ML Gao, WL Deng, KC Wu, S Sugita… - Progress in retinal and …, 2019 - Elsevier
Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …
Neuronal specification in space and time
I Holguera, C Desplan - Science, 2018 - science.org
To understand how neurons assemble to form functional circuits, it is necessary to obtain a
detailed knowledge of their diversity and to define the developmental specification programs …
detailed knowledge of their diversity and to define the developmental specification programs …