Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …

Cell types are the basic building blocks of multicellular organisms and are extensively
diversified in animals. Despite recent advances in characterizing cell types, classification …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

In the retina, photoreceptors pass visual information to interneurons, which process it and
pass it to retinal ganglion cells (RGCs). Axons of RGCs then travel through the optic nerve …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the developing retina. Little is known on the molecular basis …

The plasticity of pluripotent stem cells provides new possibilities for studying development,
degeneration, and regeneration. Protocols for the differentiation of retinal organoids from …

Clinical and genetic heterogeneity associated with retinal diseases makes stem-cell-based
therapies an attractive strategy for personalized medicine. However, we have limited …

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

To understand how neurons assemble to form functional circuits, it is necessary to obtain a
detailed knowledge of their diversity and to define the developmental specification programs …