Oxidative stress defines a condition in which the prooxidant–antioxidant balance in the cell
is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Organismal life encounters reactive oxidants from internal metabolism and environmental
toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are …

Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

The transcription factor Nrf2 (NF-E2-related factor 2) plays a vital role in maintaining cellular
homeostasis, especially upon the exposure of cells to chemical or oxidative stress, through …

Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

Regulation of transcription factor Nrf2 (NF-E2-related factor 2) involves redox-sensitive
proteasomal degradation via the E3 ubiquitin ligase Keap1/Cul3. However, Nrf2 is …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …