Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Interleukin (IL)-33 is a key cytokine involved in type-2 immunity and allergic airway disease.
At the level of lung epithelial cells, where it is clearly expressed, IL-33 plays an important …

Rationale: The alarmins IL-33 and HMGB1 (high mobility group box 1) contribute to type 2
inflammation and asthma pathogenesis. Objectives: To determine whether P2Y13-R (P2Y13 …

310 LETTERS TO THE EDITOR patients with psoriasis, an increased prevalence of
cardiovascular risk factors but possibly also proinflammatory mediators appears to …

Background Rhinovirus infections commonly evoke asthma exacerbations in children and
adults. Recurrent asthma exacerbations are associated with injury-repair responses in the …

In atopic diseases, the epithelium releases cytokines and chemokines that initiate skin
inflammation. Atopic dermatitis (AD) is characterized by a disrupted epidermal barrier and is …

Infants are exposed to a wide range of potential pathogens in the first months of life.
Although maternal antibodies acquired transplacentally protect full-term neonates from …

The epithelial cell–derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP)
initiate type 2 inflammation in allergic diseases, including asthma. However, the signaling …

Abstract Background Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its
possible involvement in the pathophysiology of COPD and viral-induced exacerbations has …

Growing awareness of the multiplicity of roles for the IL‐1 family in immune regulation has
prompted research exploring these cytokines in the context of vaccine‐induced immunity …