Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

[HTML][HTML] Oxidative stress: a unifying paradigm in hypertension

RM Touyz, FJ Rios, R Alves-Lopes, KB Neves… - Canadian journal of …, 2020 - Elsevier
The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

NOX dependent ROS generation and cell metabolism

T Pecchillo Cimmino, R Ammendola… - International Journal of …, 2023 - mdpi.com
Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic
natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS …

Protective effects of estrogen on cardiovascular disease mediated by oxidative stress

D Xiang, Y Liu, S Zhou, E Zhou… - Oxidative medicine and …, 2021 - Wiley Online Library
Perimenopause is an important stage of female senescence. Epidemiological investigation
has shown that the incidence of cardiovascular disease in premenopausal women is lower …

NADPH oxidase family proteins: signaling dynamics to disease management

R Begum, S Thota, A Abdulkadir, G Kaur… - Cellular & Molecular …, 2022 - nature.com
Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation

SS Xie, Y Deng, S Guo, J Li, Y Zhou, J Liao, D Wu… - Scientific reports, 2022 - nature.com
Inflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of
cell death that is triggered by iron-dependent lipid peroxidation and contributes to the …

[HTML][HTML] Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

SA Mason, AJ Trewin, L Parker, GD Wadley - Redox biology, 2020 - Elsevier
Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …

Squalene: more than a step toward sterols

M Micera, A Botto, F Geddo, S Antoniotti, CM Bertea… - Antioxidants, 2020 - mdpi.com
Squalene (SQ) is a natural triterpene widely distributed in nature. It is a metabolic
intermediate of the sterol biosynthetic pathway and represents a possible target in different …

Multifunctional integrated nanozymes facilitate spinal cord regeneration by remodeling the extrinsic neural environment

T Xiong, K Yang, T Zhao, H Zhao, X Gao… - Advanced …, 2023 - Wiley Online Library
High levels of reactive oxygen species (ROS) and inflammation create a complicated
extrinsic neural environment that dominates the initial post‐injury period after spinal cord …

[HTML][HTML] Redox basis of exercise physiology

NV Margaritelis, V Paschalis, AA Theodorou… - Redox biology, 2020 - Elsevier
Redox reactions control fundamental processes of human biology. Therefore, it is safe to
assume that the responses and adaptations to exercise are, at least in part, mediated by …