Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer
H Zhou, L Zhu, J Song, G Wang, P Li, W Li, P Luo… - Molecular cancer, 2022 - Springer
Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading
cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by …
cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by …
Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors
M Yi, D Jiao, H Xu, Q Liu, W Zhao, X Han, K Wu - Molecular cancer, 2018 - Springer
Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a
negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD …
negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD …
Prognostic and predictive impact of circulating tumor DNA in patients with advanced cancers treated with immune checkpoint blockade
The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced
cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n= 978) …
cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n= 978) …
[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management
AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
Liquid biopsies come of age: towards implementation of circulating tumour DNA
Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …
[HTML][HTML] How liquid biopsies can change clinical practice in oncology
G Siravegna, B Mussolin, T Venesio, S Marsoni… - Annals of …, 2019 - Elsevier
Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of
circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a …
circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a …
Early assessment of lung cancer immunotherapy response via circulating tumor DNA
SB Goldberg, A Narayan, AJ Kole, RH Decker… - Clinical Cancer …, 2018 - AACR
Purpose: Decisions to continue or suspend therapy with immune checkpoint inhibitors are
commonly guided by tumor dynamics seen on serial imaging. However, immunotherapy …
commonly guided by tumor dynamics seen on serial imaging. However, immunotherapy …
Dynamics of tumor and immune responses during immune checkpoint blockade in non–small cell lung cancer
Despite the initial successes of immunotherapy, there is an urgent clinical need for
molecular assays that identify patients more likely to respond. Here, we report that …
molecular assays that identify patients more likely to respond. Here, we report that …
Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection
C Fiala, EP Diamandis - BMC medicine, 2018 - Springer
Various recent studies have focused on analyzing tumor genetic material released into the
blood stream, known as circulating tumor DNA (ctDNA). Herein, we describe current …
blood stream, known as circulating tumor DNA (ctDNA). Herein, we describe current …
[HTML][HTML] Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer
F Cheng, L Su, C Qian - Oncotarget, 2016 - ncbi.nlm.nih.gov
Tissue biopsy is the standard diagnostic procedure for cancers and also provides a material
for genotyping, which can assist in the targeted therapies of cancers. However, tissue biopsy …
for genotyping, which can assist in the targeted therapies of cancers. However, tissue biopsy …