Hypoxia, metabolism and immune cell function
E Krzywinska, C Stockmann - Biomedicines, 2018 - mdpi.com
Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to
inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key …
inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key …
Hypoxia alters the expression of CC chemokines and cc chemokine receptors in a tumor–a literature review
J Korbecki, K Kojder, K Barczak, D Simińska… - International journal of …, 2020 - mdpi.com
Hypoxia, ie, oxygen deficiency condition, is one of the most important factors promoting the
growth of tumors. Since its effect on the chemokine system is crucial in understanding the …
growth of tumors. Since its effect on the chemokine system is crucial in understanding the …
The asparagine hydroxylase FIH: a unique oxygen sensor
YL Volkova, C Pickel, AE Jucht, RH Wenger… - Antioxidants & redox …, 2022 - liebertpub.com
Significance: Limited oxygen availability (hypoxia) commonly occurs in a range of
physiological and pathophysiological conditions, including embryonic development …
physiological and pathophysiological conditions, including embryonic development …
Role of copper in regression of cardiac hypertrophy
L Zheng, P Han, J Liu, R Li, W Yin, T Wang… - Pharmacology & …, 2015 - Elsevier
Pressure overload causes an accumulation of homocysteine in the heart, which is
accompanied by copper depletion through the formation of copper–homocysteine …
accompanied by copper depletion through the formation of copper–homocysteine …
FIH is an oxygen sensor in ovarian cancer for G9a/GLP-driven epigenetic regulation of metastasis-related genes
The prolyl hydroxylase domain-containing proteins (PHD1-3) and the asparaginyl
hydroxlyase factor inhibiting HIF (FIH) are oxygen sensors for hypoxia-inducible factor …
hydroxlyase factor inhibiting HIF (FIH) are oxygen sensors for hypoxia-inducible factor …
HIF-1α is a potential molecular target for herbal medicine to treat diseases
RL Li, LY He, Q Zhang, J Liu, F Lu… - Drug design …, 2020 - Taylor & Francis
HIF-1α is an important factor regulating oxygen balance in mammals, and its expression is
closely related to various physiological and pathological conditions of the body. Because …
closely related to various physiological and pathological conditions of the body. Because …
Molecular mechanisms regulating macrophage response to hypoxia
MA Rahat, H Bitterman, N Lahat - Frontiers in immunology, 2011 - frontiersin.org
Monocytes and Macrophages (Mo/Mφ) exhibit great plasticity, as they can shift between
different modes of activation and, driven by their immediate microenvironment, perform …
different modes of activation and, driven by their immediate microenvironment, perform …
[HTML][HTML] FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α
The N-terminal acetyltransferase A (NatA) complex, which is composed of NAA10 and
NAA15, catalyzes N-terminal acetylation of many proteins in a co-translational manner …
NAA15, catalyzes N-terminal acetylation of many proteins in a co-translational manner …
Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH
Abstract Hypoxia-inducible factor 1 (HIF-1) is a key player in cellular response to hypoxia.
The stability and transcriptional activity of this protein are oxygen-dependently regulated by …
The stability and transcriptional activity of this protein are oxygen-dependently regulated by …