Plant-derived medicines for treatment of endometriosis: A comprehensive review of molecular mechanisms

F Bina, S Soleymani, T Toliat, M Hajimahmoodi… - Pharmacological …, 2019 - Elsevier
Endometriosis is an estrogen-dependent disease with inflammatory lesions at extra-uterine
sites, causing pelvic pain and fertility reduction. Conventional therapies primarily focus on …

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

Q Wang, ZN Shen, SJ Zhang, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Neurological diseases impose a tremendous and increasing burden on global health, and
there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried …

Ligustrazine suppresses neuron apoptosis via the Bax/Bcl‐2 and caspase‐3 pathway in PC12 cells and in rats with vascular dementia

T Zhao, Y Fu, H Sun, X Liu - IUBMB life, 2018 - Wiley Online Library
The aim of this study was to examine the comprehensive neuroprotective mechanism of
ligustrazine, which is extracted from Ligusticum Chuanxiong Hort., against vascular …

Puerarin protects against high‐fat high‐sucrose diet‐induced non‐alcoholic fatty liver disease by modulating PARP‐1/PI3K/AKT signaling pathway and facilitating …

S Wang, FJ Yang, LC Shang, YH Zhang… - Phytotherapy …, 2019 - Wiley Online Library
As yet, there was no effective pharmacological therapy approved for non‐alcoholic fatty liver
disease (NAFLD). Here, we aimed to evaluate the therapeutic potential of puerarin against …

[HTML][HTML] Puerarin inhibits FUNDC1-mediated mitochondrial autophagy and CSE-induced apoptosis of human bronchial epithelial cells by activating the PI3K/AKT …

L Wang, W Jiang, J Wang, Y Xie, W Wang - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Increasing evidence suggests that the pathogenesis of chronic obstructive pulmonary
disease (COPD) is associated with FUN14 domain protein 1 (FUNDC1)-mediated …

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway

K Jiang, H Chen, K Tang, W Guan… - Oncology …, 2018 - spandidos-publications.com
Puerarin, as a novel oncotherapeutic agent, may exert anticancer effects and inhibit the
proliferation of cancer cells. To explore the effects of puerarin on human bladder cancer …

The Flavonoid Jaceosidin from Artemisia princeps Induces Apoptotic Cell Death and Inhibits the Akt Pathway in Oral Cancer Cells

HY Han, HJ Kim, SH Jeong, J Kim… - Evidence‐Based …, 2018 - Wiley Online Library
Jaceosidin is a single compound from the Japanese mugwort Artemisia princeps, which is
used as a food and a traditional medicinal herb. A. princeps extracts and flavonoid …

Unveiling the neuroprotective properties of isoflavones: current evidence, molecular mechanisms and future perspectives

G Gong, K Ganesan, Y Wan, Y Liu… - Critical Reviews in …, 2024 - Taylor & Francis
Neurodegenerative diseases encompass a wide range of debilitating and incurable brain
disorders characterized by the progressive deterioration of the nervous system's structure …

[HTML][HTML] miR-16-5p and miR-145-5p trigger apoptosis in human gingival epithelial cells by down-regulating BACH2

X Liu, K Su, S Kuang, M Fu, Z Zhang - International Journal of …, 2020 - ncbi.nlm.nih.gov
Background: Periodontitis is the second most common dental disease worldwide. TNF-α is
up-regulated in periodontal disease and induces inflammation and cell apoptosis in gingival …

[HTML][HTML] Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx

W Li, M Lu, Y Zhang, D Xia, Z Chen… - international …, 2017 - spandidos-publications.com
Abstract Puerarin extracted from Radix Puerariae is well known for its pharmacological
effects, including antioxidant, anti‑inflammatory, neuroprotective and cardioprotective …