Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …

Abstract Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA
synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A …

Abstract 1, 2, 3, 4, 6-Penta-O-Galloyl-β-d-Glucose (PGG) is a hydrolysable tannin that
belongs to the group of gallotannins but also participates in the formation of ellagitannins …

Highlights•High ALDH expression in CSCs is associated with a worse prognosis.•ALDH
isozyme expression can to some extent be cancer specific.•Rational approach to chemical …

Metabolite profiling of cancer cells presents many opportunities for anticancer drug
discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of …

In the last years, metabolic reprogramming became a new key hallmark of tumor cells. One
of its components is a deviant energetic metabolism, known as Warburg effect—an aerobic …

Abstract Penta-O-galloyl-d-glucose (PGG) is a simple hydrolysable tannin in plants. PGG
exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide …

Our recent studies have demonstrated multiple health-promoting benefits from black walnut
kernels. These biological functions of black walnuts are likely associated with their bioactive …

Introduction. In the discovery of more potent and selective anticancer drugs, the research
continually expands and explores new bioactive metabolites coming from different natural …