Transposable elements are discrete mobile DNA segments that can insert into
nonhomologous target sites. Diverse patterns of target site selectivity are observed: Some …

In this chapter, we provide an overview of the fundamental concepts of DNA transposition
mechanisms. Our aim is to emphasize basic themes and, in this effort, we will focus on …

Existing technologies for site-specific integration of kilobase-sized DNA sequences in
bacteria are limited by low efficiency, a reliance on recombination, the need for multiple …

▪ Abstract Transposable elements appear quite disparate in their organization and in the
types of genetic rearrangements they promote. In spite of this diversity, retroviruses and …

In bacteria, two categories of specialised recombination promote a variety of DNA
rearrangements. Transposition is the process by which genetic elements move between …

DNA transposons are defined segments of DNA that are able to move from one genomic
location to another. Movement is facilitated by one or more proteins, called the transposase …

One of the adjuncts to DNA replication and repair is the formation of occasional
chromosomal rearrangements—deletions, tandem duplications, and inversions. Several …

Most transposable elements move at low frequencies and insert into many different target
sites, displaying only modest or little target site-selectivity. The bacterial transposon Tn7 (B …

Tn10 is a composite transposon. It comprises a pair of IS10 insertion sequences located in
opposite orientation flanking~ 6.7 kb of unique sequences; these unique sequences encode …

Transposable elements (TEs) are nearly ubiquitous in eukaryotes. The increase in genomic
data, as well as progress in genome annotation and molecular biology techniques, have …