Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children
in North America and one of the leading causes of death of infants less than 1 year of age …

Background Metagenomic next-generation sequencing (mNGS) has changed the diagnosis
landscape of lower respiratory tract infections (LRIs). With the development of newer …

Background Human infections with different avian influenza viruses—eg, H5N1, H9N2, and
H7N9—have raised concerns about pandemic potential worldwide. We report the first …

Background Bloodstream infections remain one of the major challenges in intensive care
units, leading to sepsis or even septic shock in many cases. Due to the lack of timely …

Abstract Studies have demonstrated that~ 60%–80% of emerging infectious diseases (EIDs)
in humans originated from wild life. Bats are natural reservoirs of a large variety of viruses …

How virulence evolves after a virus jumps to a new host species is central to disease
emergence. Our current understanding of virulence evolution is based on insights drawn …

Next-generation DNA sequencing has revolutionized genomic studies and is driving the
implementation of precision diagnostics. The ability of these technologies to disentangle …

Background Rodents represent around 43% of all mammalian species, are widely
distributed, and are the natural reservoirs of a diverse group of zoonotic viruses, including …

Over the past decade, researchers have begun to characterize viral diversity using
metagenomic methods. These studies have shown that viruses, the majority of which infect …

The advances in experimental methods and the development of high performance
bioinformatic tools have substantially improved our understanding of microbial communities …