Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

Metabolism is highly complex and involves thousands of different connected reactions; it is
therefore necessary to use mathematical models for holistic studies. The use of …

Dysregulated metabolism is a hallmark of cancer, manifested through alterations in
metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell …

INTRODUCTION Metabolism is among the most strongly conserved processes across all
domains of life and is crucial for both bioengineering and disease research, yet we still have …

Turnover numbers, also known as k cat values, are fundamental properties of enzymes.
However, k cat data are scarce and measured in vitro, thus may not faithfully represent the in …

Critical to a sustainable energy future are microbial platforms that can process aromatic
carbons from the largely untapped reservoir of lignin and plastic feedstocks. Comamonas …

Protein synthesis is the most energy-consuming process in a proliferating cell, and
understanding what controls protein abundances represents a key question in biology and …

Maximization of growth rate is an important fitness strategy for bacteria. Bacteria can achieve
this by expressing proteins at optimal concentrations, such that resources are not wasted …

Reacting to environmental exposure, most higher plants activate secondary metabolic
pathways, such as the metabolism of phenylpropanoids. This pathway results in the …

Based on technical advances in the sequencing and synthesis of genetic components as
well as the genome, significant progress has recently been made in developing synthetic …