Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that
primarily affects motor neurons in the brain and spinal cord. In the recent past, there have …

Objective To compare the effect of riluzole on median survival in population studies of
patients with amyotrophic lateral sclerosis (ALS) with that observed in clinical trials …

In 2015, a total of 16,583 persons were identified as having definite ALS. The estimated
prevalence of ALS in 2015 was 5.2 per 100,000 population, which is similar to that in 2014 …

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

In recent years, the overuse of antibiotics has resulted in the emergence of antibiotic
resistance, which is a serious global health problem. Methicillin-resistant Staphylococcus …

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease
characterized by a permanent degeneration of both upper and lower motor neurons. Many …

Alterations in upper motor neuron excitability are one of the earliest phenomena clinically
detected in ALS, and in 97% of cases, the RNA/DNA binding protein, TDP-43, is …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by
the death of motor neurons. Riluzole is a benzothiazole derivative that blocks glutamatergic …

The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat
(EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and …

In recent years, unique physicochemical properties of amphiphilic block copolymers have
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …