The procurement and management of nutrients and ability to fight infections are fundamental
requirements for survival. These defense responses are bioenergetically costly, requiring …

Since the discovery of the nuclear factor kappa B (NF-ĸB) transcription factor 36 years ago,
many studies have linked the NF-ĸB signaling pathway to pathological and physiological …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Background Aerobic glycolysis has been recognized as one of the growth-promoting
metabolic alterations of cancer cells. Emerging evidence indicates that nuclear factor κB (NF …

Impairment of innate immune cell function and metabolism underlies immunosuppression in
sepsis; however, a promising therapy to orchestrate this impairment is currently lacking. In …

The public health issue of glucolipid metabolic disorders (GLMD) has grown significantly,
posing a grave threat to human wellness. Its prevalence is rising yearly and tends to affect …

In metabolic conditions such as obesity and diabetes, which are associated with
deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation …

We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to
describe the DNA methylation signature of chronic low-grade inflammation as measured by …

Mercury (Hg) is a persistent heavy metal contaminant with definite hepatotoxicity. Selenium
(Se) has been shown to alleviate liver damage induced by heavy metals. Therefore, the …

Objective Obesity-associated chronic inflammation, aka meta-inflammation, is a key
pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue …