Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
[HTML][HTML] Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses
DM Morens, JK Taubenberger, AS Fauci - Cell host & microbe, 2023 - cell.com
Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
COVID-19 and cellular senescence
CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
Damage to endothelial barriers and its contribution to long COVID
X Wu, M Xiang, H Jing, C Wang, VA Novakovic, J Shi - Angiogenesis, 2024 - Springer
The world continues to contend with COVID-19, fueled by the emergence of viral variants. At
the same time, a subset of convalescent individuals continues to experience persistent and …
the same time, a subset of convalescent individuals continues to experience persistent and …
[PDF][PDF] The vascular perspective on acute and chronic lung disease
I Borek, A Birnhuber, NF Voelkel… - Journal of Clinical …, 2023 - Am Soc Clin Investig
The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …
COVID-19 and the vasculature: current aspects and long-term consequences
B Martinez-Salazar, M Holwerda, C Stuedle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
MR Stutz, NP Dylla, SD Pearson… - Nature …, 2022 - nature.com
Respiratory failure and mortality from COVID-19 result from virus-and inflammation-induced
lung tissue damage. The intestinal microbiome and associated metabolites are implicated in …
lung tissue damage. The intestinal microbiome and associated metabolites are implicated in …
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
R Mothes, A Pascual-Reguant, R Koehler… - Nature …, 2023 - nature.com
Prolonged lung pathology has been associated with COVID-19, yet the cellular and
molecular mechanisms behind this chronic inflammatory disease are poorly understood. In …
molecular mechanisms behind this chronic inflammatory disease are poorly understood. In …
Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis
X Tang, J Liu, S Yao, J Zheng, X Gong… - Pharmaceutical …, 2022 - Taylor & Francis
Context Ferulic acid (FA) has antioxidative and anti-inflammatory effects, and is a promising
drug to treat sepsis. Objective To study the therapeutic effect of FA in sepsis-induced acute …
drug to treat sepsis. Objective To study the therapeutic effect of FA in sepsis-induced acute …