Lupus nephritis (LN) represents the most severe organ manifestation of systemic lupus
erythematosus (SLE) in terms of morbidity and mortality. To reduce these risks, tremendous …

Lupus nephritis (LN), a major complication in individuals diagnosed with systemic lupus
erythematosus, substantially increases morbidity and mortality. Despite marked …

UNC93B1 is a transmembrane domain protein mediating the signaling of endosomal Toll-
like receptors (TLRs). We report five families harboring rare missense substitutions (I317M …

Understanding the pathogenesis and clinical manifestations of systemic lupus
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …

TLR7 recognizes pathogen-derived single-stranded RNA (ssRNA), a function integral to the
innate immune response to viral infection. Notably, TLR7 can also recognize self-derived …

Systemic lupus erythematosus (SLE) is an autoimmune disorder intricately linked to genetic
factors, with numerous approaches having identified genes linked to its development …

Lupus nephritis (LN) is the most severe end-organ pathology in Systemic Lupus
Erythematosus (SLE). Research has enhanced our understanding of immune effectors and …

Early-onset systemic lupus erythematosus presents with a more severe disease and is
associated with a greater genetic burden, especially in patients from Black, Asian or …

Systemic lupus erythematosus is a rare and life-threatening autoimmune disease
characterized by autoantibodies against double-stranded DNA, with an immunopathology …

Monogenic lupus: insights into disease pathogenesis and ther... : Current Opinion in
Rheumatology Monogenic lupus: insights into disease pathogenesis and therapeutic …