Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, fatal disorder with no effective
treatment. We used simple genetic models of ALS to screen phenotypically for potential …

The historical view that Amyotrophic Lateral Sclerosis (ALS) as a pure motor disorder has
been increasingly challenged by the discovery of cognitive and behavioral changes in the …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive fatal neurodegenerative disease
affecting one in 350 people. The aim of Project MinE is to elucidate the pathophysiology of …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends
of a disease spectrum with shared clinical, genetic and pathological features. These include …

The blood‐brain barrier (BBB) and the blood‐spinal cord barrier (BSCB) are responsible for
controlling the microenvironment within neural tissues in humans. These barriers are …

Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have
long been proposed to contribute to the development of schizophrenia, and accumulating …

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder without effective
neuroprotective therapy. Known genetic variants impair pathways, including RNA …

Glycosylation is a common post-translational modification of brain proteins including cell
surface adhesion molecules, synaptic proteins, receptors and channels, as well as …

Advanced neuroimaging has increased understanding of the pathogenesis and spread of
disease, and offered new therapeutic targets. MRI and positron emission tomography have …

In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases,
focusing on Alzheimer's disease (AD). We summarize the various techniques developed to …