[HTML][HTML] The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases
The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …
Changing landscape of anti-angiogenic therapy: Novel approaches and clinical perspectives
RN Gacche - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Targeting angiogenesis has remained one of the important aspects in disease biology in
general and cancer in particular. Currently (June 2023), over 593 clinical trials have been …
general and cancer in particular. Currently (June 2023), over 593 clinical trials have been …
Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy
X Chen, Y Wang, JN Wang, YC Zhang… - EMBO Molecular …, 2024 - embopress.org
Diabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age
populations. Fat mass and obesity-associated protein (FTO) is an N6-methyladenosine …
populations. Fat mass and obesity-associated protein (FTO) is an N6-methyladenosine …
Vascular function: a key player in hypertension
H Tomiyama - Hypertension Research, 2023 - nature.com
The major functions of the arterial system are to “efficiently deliver blood to the peripheral
organs and maintain vascular homeostasis”. Both the endothelial and medial layer …
organs and maintain vascular homeostasis”. Both the endothelial and medial layer …
[HTML][HTML] Podocytopathy: The role of actin cytoskeleton
E Ahmadian, A Eftekhari, S Atakishizada… - Biomedicine & …, 2022 - Elsevier
Renal injury and the development of albuminuria are tightly connected with the loss of
podocytes. Podocyte damages cause proteinuric renal diseases since podocyte foot …
podocytes. Podocyte damages cause proteinuric renal diseases since podocyte foot …
[HTML][HTML] Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial …
C Xue, K Chen, Z Gao, T Bao, LS Dong, L Zhao… - Cell Communication and …, 2023 - Springer
Diabetic vascular complications (DVCs), including macro-and micro-angiopathy, account for
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …
AR/RKIP pathway mediates the inhibitory effects of icariin on renal fibrosis and endothelial-to-mesenchymal transition in type 2 diabetic nephropathy
W Yao, R Tao, Y Xu, ZS Chen, X Ding, L Wan - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Herba epimedium brevicornu maxim is traditionally known
as a sexual enhancement, and has the effect of tonifying kidney yang. Icariin is a flavonoid …
as a sexual enhancement, and has the effect of tonifying kidney yang. Icariin is a flavonoid …
Corpora cavernosa fibroblasts mediate penile erection
EL Guimaraes, DO Dias, WF Hau, A Julien, D Holl… - Science, 2024 - science.org
Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed that
enlarges upon vasodilation, but its regulation is not completely understood. Here, we show …
enlarges upon vasodilation, but its regulation is not completely understood. Here, we show …
[HTML][HTML] The role of endothelial cell–pericyte interactions in vascularization and diseases
G Li, J Gao, P Ding, Y Gao - Journal of Advanced Research, 2024 - Elsevier
Abstract Background Endothelial cells (ECs) and pericytes (PCs) are crucial components of
the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding …
the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding …
[HTML][HTML] AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice
S Zhang, X Tong, S Liu, J Huang, L Zhang… - Cell Death & …, 2023 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a devastating fibrotic lung disease characterized by
scarring and destruction of the lung architecture, with limited treatment options. Targeted …
scarring and destruction of the lung architecture, with limited treatment options. Targeted …